{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:25Z","timestamp":1790622085187,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The therapeutic landscape for older adults with acute myeloid leukemia (AML) has undergone a major paradigm shift with the advent of lower\u2010intensity targeted regimens, particularly hypomethylating agents combined with venetoclax. As treatment transitions from acute induction to prolonged, multi\u2010cycle administration, clinical success increasingly depends on the patient's capacity to sustain repeated cycles, manage cytopenias and infections, and maintain functional independence. Current precision oncology models excel at characterizing the leukemic clone via cytogenetics, genomics, and measurable residual disease (MRD); however, they provide limited insight into the patient's underlying biological reserve. In this perspective, we propose\n                    <jats:italic>host fitness<\/jats:italic>\n                    as a critical, complementary dimension of precision medicine in older AML. Host fitness is a dynamic, multidimensional construct encompassing functional reserve, body composition, nutritional status, immune competence, inflammatory burden, and metabolic resilience. Moving beyond traditional performance status and simplistic metrics like body mass index, longitudinal assessment of host fitness aims to identify actionable vulnerabilities, guide targeted supportive interventions, and optimize treatment persistence. Integrating continuous host\u2010fitness evaluation with clonal profiling establishes a dual host\u2013tumor precision\u2010medicine framework designed to maximize therapeutic efficacy while preserving patient resilience and quality of life.\n                  <\/jats:p>","DOI":"10.1002\/hon.70249","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:43:25Z","timestamp":1790617405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host Fitness: A Missing Dimension of Precision Medicine in Older Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"44","author":[{"given":"Fortunato","family":"Morabito","sequence":"first","affiliation":[{"name":"Dafne Srl  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Bruzzese","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Hematology Unit AO of Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8504-3231","authenticated-orcid":false,"given":"Enrica Antonia","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Hematology Unit AO of Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Amodio","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Vigna","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Hematology Unit AO of Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-0726","authenticated-orcid":false,"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Hematology Unit AO of Cosenza  Cosenza Italy"},{"name":"Department of Pharmacy, Health and Nutritional Science University of Calabria  Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001239"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.07.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201012\u2010471680"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.8687"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70153\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2017.08.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb06651.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000243"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bneo.2024.100017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010026\u201050426\u20100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010025\u201004093\u2010y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.70198"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18051"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000930"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01546"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010026\u201003024\u2010y"},{"issue":"1","key":"e_1_2_9_24_1","first-page":"16","article-title":"Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. 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