{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:46:31Z","timestamp":1792406791263,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Monomorphic epitheliotropic intestinal T\u2010cell lymphoma (MEITL) is a rare, aggressive intestinal T\u2010cell lymphoma with poorly defined prognostic factors and limited therapeutic evidence. This study presents a retrospective, pooled patient\u2010level analysis of MEITL cases, including those previously classified as type II enteropathy\u2010associated T\u2010cell lymphoma, consistent with modern MEITL criteria. Among 299 patients, the median age was 60\u00a0years, with a male preponderance. Cases clustered predominantly in East Asia. Abdominal pain was the most frequent presentation, and perforation occurred in 31.9% of cases. The canonical CD3+, CD4\u2212, CD5\u2212, CD8+, CD56+ phenotype was present in 65.9% of fully annotated cases. Median OS was 12\u00a0months, and median PFS was 5\u00a0months. Elevated LDH \u2265\u00a0250 U\/L (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002), advanced Lugano stage II2\/IIE\/IV (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.042), and non\u2010ileal\u2010only disease distribution were associated with inferior OS, whereas isolated ileal involvement was favorable (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004). In multivariable analysis, advanced Lugano stage, non\u2010ileal\u2010only involvement, and failure to achieve complete or partial response remained independently adverse. An exploratory prognostic score incorporating stage, anatomic distribution, and LDH showed preliminary risk group separation in a small subset of patients (C\u2010index 0.734). Stem cell transplantation (SCT) was associated with improved survival in fixed\u2010time analyses, but this association was attenuated after accounting for transplant timing; exploratory responder\u2010restricted and landmark analyses suggested that any potential SCT benefit may be concentrated among patients with chemotherapy\u2010sensitive disease. MEITL demonstrates poor survival despite multimodality therapy. Disease extent, anatomic distribution, LDH, treatment response, and response\u2010adapted SCT may inform risk stratification and management.\n                  <\/jats:p>","DOI":"10.1002\/hon.70262","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:12:18Z","timestamp":1789841538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Survival Determinants of Monomorphic Epitheliotropic T\u2010Cell Lymphoma: A Pooled Patient\u2010Level Dataset Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-069X","authenticated-orcid":false,"given":"Philip A.","family":"Haddad","sequence":"first","affiliation":[{"name":"Feist\u2010Weiller Cancer Center Louisiana State University Health Science Center  Shreveport Louisiana USA"},{"name":"Hematology\u2010Oncology Section Overton Brooks VA Medical Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-3467","authenticated-orcid":false,"given":"Supriya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Hematology, Oncology, and Transplantation Department University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1112-9171","authenticated-orcid":false,"given":"Ankita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology Section Overton Brooks VA Medical Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-0329","authenticated-orcid":false,"given":"Christopher","family":"Graham","sequence":"additional","affiliation":[{"name":"Hematology, Oncology, and Transplantation Department University of Minnesota  Minneapolis Minnesota 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