{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:46:29Z","timestamp":1792406789711,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although clinical trials showed outcomes improvement in MCL, their applicability to real\u2010world practice remains limited. Using the prospective REALYSA registry (NCT03869619), we evaluated contemporary management, highlighting evolving practices and differences by age. Among 295 patients, 63% were \u2265\u00a065\u00a0years, 48% had a high\u2010risk MIPI score with Ki\u201067\u00a0\u2265\u00a030% in 53% and aggressive morphology in 11%. Younger patients received high\u2010dose cytarabine (93%) and ASCT (78%). Older patients were treated with bendamustine\u2010rituximab (28%), R\u2010CHOP (18%), and low\u2010dose cytarabine (20%). Two\u2010year event\u2010free (EFS\u20102y) and overall (OS\u20102y) survivals were 80% and 89% in &lt;\u00a065y; 60% and 77% in \u2265\u00a065y. Among 238 patients responders after induction, rituximab maintenance (RM) use was frequent but lower in older patients (88% vs. 76%). In time\u2010dependent Cox models adjusted for age (&lt; 65 vs. \u2265\u00a065) and MIPI, RM was associated with a lower hazard of EFS events (HR 0.48; 95% CI: 0.25\u20130.92), although residual confounding related to treatment selection may remain. In the second\u2010line setting (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a072), most patients were POD24 (89%) and 56% received ibrutinib, yet outcomes remained poor (CR 24%, ORR 35%, median EFS and OS of 6.3 and 25.6\u00a0months, respectively). These findings underscore the need for improved strategies for older and high\u2010risk patients. Retrospective landmark analyses suggest a potential association between RM and improved EFS but are limited by baseline differences between groups.\n                  <\/jats:p>","DOI":"10.1002\/hon.70264","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:26:33Z","timestamp":1790036793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contemporary Treatment and Survival Outcomes in Mantle Cell Lymphoma: A National Real\u2010World Analysis From REALYSA, a LYSA Cohort"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2070-9581","authenticated-orcid":false,"given":"Morgane","family":"Cheminant","sequence":"first","affiliation":[{"name":"Department of Haematology Necker\u2010Enfants Malades University Hospital Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Laboratory of Hematological Disorders INSERM UMR1163 Institut Imagine Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0076-0794","authenticated-orcid":false,"given":"Patrick","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Lymphoma Academic Research Organisation Hopital Lyon Sud Pierre Benite  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Carras","sequence":"additional","affiliation":[{"name":"Department of Haematobiology Centre Hospitalier Universitaire de Grenoble  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Department of Haematology Institut Curie, Saint Cloud Universit\u00e9 de Versailles Saint\u2010Quentin (UVSQ)  Saint\u2010Cloud 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