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These universally available, off\u2010the\u2010shelf products have demonstrated unprecedented efficacy in heavily pretreated patients with relapsed\/refractory (R\/R) hematological malignancies (HMs). The indefinite treatment duration associated with most BsAb products, coupled with neutropenia, B\u2010cell aplasia, and hypogammaglobulinemia result in significant immune\u2010related toxicities and infections. Hence, non\u2010relapse mortality (NRM) which represents the cumulative burden of treatment\u2010related toxicities, defined as death from any cause other than disease relapse or progression, is a patient\u2010centric endpoint across cellular therapy platforms. While recent NRM estimates with CAR T\u2010cell therapy have identified infections as major drivers of NRM, real\u2010world NRM estimates remain limited with BsAbs. To mitigate the limitations associated with each of the methods, we conducted a systematic review and meta\u2010analysis of the existing literature, supplemented concurrently by a pharmacovigilance analysis using the FAERS database, to estimate NRM with BsAbs and compare real\u2010world findings between commercially available BsAb products approved for relapsed\/refractory multiple myeloma (RRMM) and NHL. The primary endpoint was NRM; secondary endpoints included CRS, ICANS, infections, and death. Teclistamab demonstrated a high toxicity burden across both analytic methods, with the highest ICANS incidences, significantly greater infection rates (particularly grade &gt;\u00a03), and a non\u2010negligible NRM estimate in the SRMA as well in FAERS. Glofitamab was associated with severe toxicities, including increased reporting odds for NRM and overall mortality. Mosunetuzumab showed lower pooled estimates and lower reporting odds, as seen in both analytic approaches. Low pooled incidences of infections, and ICANS were calculated in the SRMA. FAERS analyses also suggested reduced reporting odds for NRM and neurotoxicity. While trial\u2010level data and real\u2010world reporting largely converged for severe toxicities, divergences in other agents underscore the importance of continuous post\u2010marketing surveillance. Given the risks associated with prolonged treatment, future protocols must prioritize infection management and adopt NRM as a standardized endpoint to guide appropriate therapeutic selection and sequencing.<\/jats:p>","DOI":"10.1002\/hon.70268","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:04:13Z","timestamp":1792159453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Relapse Mortality With Bispecific Antibodies in Hematologic Malignancies: A Dual Systematic Review and Pharmacovigilance Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3133-5993","authenticated-orcid":false,"given":"Sohaib","family":"Irfan","sequence":"first","affiliation":[{"name":"The Aga Khan University School of Medicine  Karachi 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