{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:55:28Z","timestamp":1790657728008,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatosplenic T\u2010cell lymphoma (HSTCL) is an ultra\u2010rare, aggressive T\u2010cell neoplasm for which evidence regarding prognosis and optimal therapy remains limited. We conducted a retrospective pooled patient\u2010level analysis of 529 patients from 198 sources. The median age was 32\u00a0years, with 71.7% male. Hepatosplenomegaly and bone marrow involvement were present in 99.7% and 91.8% of evaluable patients, respectively. Among 436 patients with evaluable overall survival (OS), the median OS was 12.0\u00a0months, and the median progression\u2010free survival was 5.0\u00a0months. Multivariable analysis demonstrated that hemoglobin less than 8\u00a0g\/dL (HR 3.36, 95% CI 1.61\u20137.00;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0012) and underlying immunosuppression (HR 3.00, 95% CI 1.77\u20135.06;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001) independently predicted inferior OS, while time\u2010dependent stem cell transplantation (SCT) was associated with improved survival (HR 0.31, 95% CI 0.15\u20130.65;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0021). A provisional two\u2010point score incorporating severe anemia and immunosuppression stratified patients into low\u2010, intermediate\u2010, and high\u2010risk groups, with median OS of 26, 5, and 3\u00a0months, respectively (log\u2010rank\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001; C\u2010index 0.706). Platinum\u2010containing first\u2010line regimens were associated with lower mortality compared to CHOP\u2010like therapy (HR 0.43, 95% CI 0.25\u20130.75;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003). The SCT survival association was consistent across complementary analyses. Nonresponsive, stable, or progressive disease at transplantation predicted inferior post\u2010transplant survival compared to complete response (HR 2.84, 95% CI 1.32\u20136.10;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.007). These findings identify severe anemia and immunosuppression as adverse prognostic features, support non\u2010CHOP platinum\u2010based induction and early SCT evaluation after disease control. However, because this is a retrospective pooled design, the treatment associations and the provisional prognostic score still require external validation.\n                  <\/jats:p>","DOI":"10.1002\/hon.70271","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:08:50Z","timestamp":1790654930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic Features and Survival Determinants of Hepatosplenic T\u2010Cell Lymphoma: A Pooled Patient\u2010Level Dataset Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-069X","authenticated-orcid":false,"given":"Philip A.","family":"Haddad","sequence":"first","affiliation":[{"name":"Feist\u2010Weiller Cancer Center Louisiana State University Health Science Center  Shreveport Louisiana USA"},{"name":"Hematology\u2010Oncology Section Overton Brooks VA Medical Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Hematology, Oncology, and Transplantation Department University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1112-9171","authenticated-orcid":false,"given":"Ankita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology Section Overton Brooks VA Medical Center  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-0329","authenticated-orcid":false,"given":"Christopher","family":"Graham","sequence":"additional","affiliation":[{"name":"Hematology, Oncology, and Transplantation Department University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004118"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.16.4558"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2216"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"160","article-title":"Hepatosplenic T\u2010Cell Lymphoma: A Population\u2010Based Study Assessing Incidence and Association With Immune\u2010Mediated Disease","volume":"11","author":"Montgomery M.","year":"2015","journal-title":"Gastroenterology and 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