{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:47:10Z","timestamp":1792043230625,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Coexistent chronic myeloid leukemia (CML) and\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative myeloproliferative neoplasms (MPN) are rare. We aimed to evaluate their clinical and therapeutic profiles. We retrospectively evaluated 36 institutional patients with coexistent CML and\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN (Cohort A) and systematically reviewed 244 published cases (Cohort B). Patients were categorized by diagnostic sequence: prior CML, prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN, or concurrent presentation.\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    p210 and\n                    <jats:italic>JAK2V617\u00a0F<\/jats:italic>\n                    aberrations predominantly co\u2010occurred. Diagnoses in Cohort A were mostly concurrent (77.8%), whereas Cohort B predominantly featured prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN (43.0%), followed by concurrent diagnoses (35.7%) and prior CML (21.3%). In Cohort B, myelofibrosis was significantly more prevalent in prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN compared to those with prior CML or concurrent diagnoses (56.2% vs. 26.9% vs. 35.6%, respectively;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.007). Persistent, unexplained cytosis despite active therapy triggered secondary mutation cross\u2010screening in both cohorts. In Cohort A, exploratory survival analysis suggested a potential trend toward shorter overall survival in prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN compared to concurrent diagnoses (90.5\u00a0months vs. not reached,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.032). Multivariable analysis of Cohort B identified prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN as an independent adverse predictor for major or deeper molecular responses (OR\u00a0=\u00a00.412, 95% CI: 0.197\u20130.861,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.018), while tyrosine kinase inhibitor (TKI)\u2010based therapy was favorable (OR\u00a0=\u00a09.74, 95% CI: 1.108\u201385.636,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.040). Addition of JAK2 inhibitors to TKI therapy did not significantly improve molecular responses over TKI monotherapy (67.1% vs. 54.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.193). To summarize, prior\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPN, the most frequent presentation, predicted inferior molecular responses. Clinicians should screen for coexistent mutations if cytosis persisted despite treatment. TKI remained the therapeutic cornerstone, as combined JAK2 inhibition demonstrated limited additional benefit.\n                  <\/jats:p>","DOI":"10.1002\/hon.70273","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:07:29Z","timestamp":1792040849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Coexistent Chronic Myeloid Leukemia and\n                    <i>BCR::ABL1<\/i>\n                    Negative Myeloproliferative Neoplasms: A Retrospective Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5667-3935","authenticated-orcid":false,"given":"Yanan","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Department of Hematology Henan Provincial People's Hospital Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Pan","sequence":"additional","affiliation":[{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunmin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology Henan Provincial People's Hospital Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-9883","authenticated-orcid":false,"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-4489","authenticated-orcid":false,"given":"Zhijian","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"MDS and MPN Centre Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 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