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We assessed remissions and survival in a cohort of 44 consecutive HIV positive patients diagnosed with SNCL at our hospital between June 2000 and November 2001 using chart and pathology data. Median follow\u2010up, survival and survival at the median follow\u2010up time were 4.5 months, 4 months and 49% respectively. Of this cohort 39% were complete responders (CR) and 36% were long\u2010term lymphoma\u2010free survivors. Two patients relapsed from CR. Short course intensive chemotherapy (McMaster) was administered to 23 patients; 17 received less intensive conventional combination chemotherapy; and four received single\u2010agent chemotherapy or no treatment. In the McMaster group, 38% (9\/23) achieved CR with no relapses. Seven patients (30%) died of toxicity compared with one (6%) in the less intensively treated group. Of the stage I patients, 75% (6\/8) achieved long\u2010term CR with half being treated conventionally. Conventional chemotherapy may be curative for early stage HIV\u2010SNCL. In advanced disease, McMaster chemotherapy was found to be associated with substantial early mortality but was curative in a significant number of patients. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.715","type":"journal-article","created":{"date-parts":[[2003,10,22]],"date-time":"2003-10-22T19:22:51Z","timestamp":1066850571000},"page":"131-140","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term survival in patients with human immunodeficiency virus\u2010associated small non\u2010cleaved cell lymphoma: the role for short course intensive chemotherapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Alan B.","family":"Astrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Tarabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent E.","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Lascher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zujun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitabha","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulfaqquar","family":"Jaffar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald H.","family":"Blum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford J.","family":"Kempin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92740-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.5.561"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.12.3788"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408303110904"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880601)61:11<2325::AID-CNCR2820611130>3.0.CO;2-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-5-744"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1182\/blood.V80.1.8.8","article-title":"Acquired immunodeficiency syndrome\u2014related lymphoma (Review)","volume":"80","author":"Levine AM","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_9_2","first-page":"322","article-title":"AIDS\u2010related malignant lymphoma: results of prospective treatment trials","volume":"5","author":"Gill PS","year":"1987","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420050069041"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/jama.1991.03470010088036","article-title":"Low\u2010dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance in AIDS\u2010related lymphoma: a prospective multi\u2010institutional trial","volume":"266","author":"Levine AM","year":"1991","journal-title":"JAMA"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199706053362304"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(97)86004-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.1991.9.6.941","article-title":"Effective treatment of small noncleaved cell lymphoma with high\u2010intensity, brief duration chemotherapy","volume":"9","author":"McMaster ML","year":"1991","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood.V81.10.2810.2810","article-title":"Infusional cyclophosphamide, doxorubicin and etoposide in human immunodeficiency virus and human T\u2010cell leukemia virus type I\u2010related non\u2010Hodgkin's lymphoma: a highly active regimen","volume":"81","author":"Sparano JA","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_16_2","first-page":"2112","article-title":"Brown BW Jr, et al. 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