{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:28:49Z","timestamp":1790666929292,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T00:00:00Z","timestamp":1125446400000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma (T\u2010AIL) is a peripheral T\u2010cell lymphoma of unknown etiology. Previous clonality studies have shown a heterogeneous composition of this disease with varying restrictions of B\u2010 and T\u2010cell populations in the tumour. For the first time in a single study and in the same pathological materials, we have analysed, lymphoid cell clonality and occurrence of human herpes viruses and Epstein Barr virus. Of 18 cases 12 (66.6%) had clonal T\u2010 and three (16.6%) had clonal B\u2010cells. Presence of the lymphotropic viral genome of HHV6 was detected in four of 18 lymph node biopsies from T\u2010AIL patients (22%), all were TCR\u03b3 clonal. No HHV8 were found. Epstein Barr genome was found in 40% of cases. There was no significant association between T\u2010cell clonality and HHV\u20106 or EBV infection, or between B\u2010cell clonality and any virus infection. We conclude that T\u2010AIL is a biologically and clinically heterogeneous entity whose true nature remains to be clarified. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.740","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T10:17:28Z","timestamp":1125483448000},"page":"169-177","source":"Crossref","is-referenced-by-count":26,"title":["T\u2010 and B\u2010cell clonality and frequency of human herpes viruses\u20106, \u20108 and Epstein Barr virus in angioimmunoblastic T\u2010cell lymphoma"],"prefix":"10.1002","volume":"22","author":[{"given":"Maruska Marusic","family":"Vrsalovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Korac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Dominis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodanka","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mannhalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajko","family":"Kusec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"225","volume-title":"World Health Organization Classification of Tumors. 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