{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:31:16Z","timestamp":1791117076235,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T00:00:00Z","timestamp":1132790400000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Splenic marginal zone lymphoma (SMZL) and nodal marginal zone lymphoma (NMZL) are newly defined, separate clinicopathological entities. Both are rare lymphoma types, with low reproducibility in the diagnosis, although a conjunction of molecular and clinical studies seems to be now facilitating a more accurate diagnosis and understanding of the neoplastic process. SMZL is a disease involving the spleen, bone marrow and peripheral blood since the initial manifestations of the disease. The diagnosis has been until very recently based on the pathological study of the spleen with the conjunction of the clinical features, although the integration of the morphology in bone marrow and peripheral blood with the immunophenotype and molecular characteristics of the tumour makes a more accurate diagnosis now possible. The most frequent molecular alteration found in SMZL is allelic loss at the 7q chromosomal region. SMZL is an indolent lymphoma, although there is small subset of patients in which it follows an aggressive course. Molecular studies of SMZL are starting to reveal new diagnostic and prognostic markers, and to identify new potentially useful therapeutic targets. Nodal marginal zone lymphoma is a B\u2010cell neoplasm originated in the lymph node, whose histology resembles the nodal infiltration by MALT\u2010 or Splenic\u2010type marginal zone lymphoma, in the absence of clinical evidence of extranodal or spleen disease. The lack of characteristic phenotypic or molecular diagnostic findings is still hampering the reproducibility of this diagnosis. Here we review the main morphological and immunophenotypical markers, discussing the differential with other overlapping entities, singularly follicular lymphoma. Specific therapeutic protocols and prognostic factors are required to more precisely define this tumour. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.762","type":"journal-article","created":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T10:47:08Z","timestamp":1132829228000},"page":"108-118","source":"Crossref","is-referenced-by-count":48,"title":["Nodal and splenic marginal zone B cell lymphomas"],"prefix":"10.1002","volume":"23","author":[{"given":"Manuela","family":"Mollejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca I","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Algara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ruiz\u2010Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,24]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"World Health Organization","year":"2001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0750"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580403.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64087-4"},{"key":"e_1_2_1_6_2","first-page":"1070","article-title":"T\u2010bet\u2010positive and IRTA1\u2010positive monocytoid B cells differ from marginal zone B cells and epithelial\u2010associated B cells in their antigen profile and topographical distribution","volume":"90","author":"Johrens K","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1182\/blood.V94.8.2800.420a01_2800_2808","article-title":"Monocytoid B cells are distinct from splenic marginal zone cells and commonly derive from unmutated naive B cells and less frequently from postgerminal center B cells by polyclonal transformation","volume":"94","author":"Stein K","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(89)80023-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01308-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","unstructured":"Analyses of the in vivo trafficking of stoichiometric doses of an anti\u2010complement receptor 1\/2 monoclonal antibody infused intravenously in mice. Vol. 173;2004.","DOI":"10.4049\/jimmunol.173.4.2297"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711480206"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199205000-00004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199510000-00005"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199705000-00051"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.11.3828.bloodjournal84113828"},{"key":"e_1_2_1_16_2","first-page":"294","article-title":"Splenic B cell lymphoma with \u2018villous\u2019 lymphocytes in the peripheral blood: a disorder distinct from hairy cell leukemia","volume":"1","author":"Melo JV","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01314.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-536.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199707000-00005"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.04.009"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2005.n.007"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65411-9"},{"key":"e_1_2_1_23_2","first-page":"71","article-title":"Splenic marginal zone B\u2010cell lymphomas: two cytogenetic subtypes, one with gain of 3q and the other with loss of 7q","volume":"86","author":"Sole F","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2837"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203033"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64140-5"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.04.026"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.1.270.270"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3552"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.51.5.262"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1299"},{"key":"e_1_2_1_32_2","first-page":"470","article-title":"Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection","volume":"90","author":"Traverse\u2010Glehen A","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402073"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3898"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2160"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60525-9"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1711"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.06.005"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)91095-1"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90211-X"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.5.1648.h81702001648_1648_1654"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00981-1"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00007"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2002.n.010"},{"key":"e_1_2_1_45_2","first-page":"249","article-title":"Successful treatment of splenic lymphoma with villous lymphocytes by rituximab and laparoscopic splenectomy","volume":"44","author":"Fujita T","year":"2003","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2004.n.005"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013376"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04165.x"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1711.x"},{"key":"e_1_2_1_50_2","first-page":"310","article-title":"Monocytoid B\u2010cell lymphoma. A novel B\u2010cell neoplasm","volume":"124","author":"Sheibani K","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.1.121"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1988.tb01953.x"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200306000-00006"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199901000-00006"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00870.x"},{"key":"e_1_2_1_56_2","first-page":"128","article-title":"Nodal monocytoid B\u2010cell lymphoma (nodal marginal\u2010zone B\u2010cell lymphoma)","volume":"36","author":"Nathwani BN","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2486"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402191"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64988-7"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb05036.x"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-6-199709150-00002"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61691-4"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2009"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.1950"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200304000-00014"},{"key":"e_1_2_1_67_2","first-page":"200","article-title":"Indolent lymphoplasmacytic and marginal zone B\u2010cell lymphomas: absence of both IRF4 and Ki67 expression identifies a better prognosis subgroup","volume":"90","author":"Petit B","year":"2005","journal-title":"Haematologica"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.762","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T16:43:56Z","timestamp":1693500236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":66,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/hon.762"],"URL":"https:\/\/doi.org\/10.1002\/hon.762","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}