{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:32:08Z","timestamp":1721889128235},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T00:00:00Z","timestamp":1144281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report describes a chronic myelogenous leukaemia patient with an apparently normal bone marrow karyotype but <jats:italic>BCR\/ABL<\/jats:italic> fusion\u2010gene\u2010positive. Commercial FISH probes showed an atypical pattern and the <jats:italic>BCR\/ABL<\/jats:italic> fusion transcript was detected by RT\u2010PCR, but not the reciprocal <jats:italic>ABL\/BCR<\/jats:italic>. Consecutive FISH assays clarified the mechanism of the masked Ph. The <jats:italic>ABL<\/jats:italic> gene and the following 5.6\u20135.7\u2009Mb of 9q are inserted into the <jats:italic>BCR<\/jats:italic> region of chromosome 22. There is no transference of 22q material to chromosome 9 or to any other chromosomes. Clinical features and evolution of the patient are similar to those cases with classic Ph chromosome. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.775","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T14:51:25Z","timestamp":1144335085000},"page":"86-88","source":"Crossref","is-referenced-by-count":6,"title":["Generation of the <i>BCR\/ABL<\/i> fusion gene in a Philadelphia chromosome\u2010negative chronic myeloid leukaemia: insertion of 5.6\u2009Mb of 9q34 into the <i>BCR<\/i> region of chromosome 22"],"prefix":"10.1002","volume":"24","author":[{"given":"Laura","family":"Valle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"P\u00e9rez\u2010Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix Garc\u00eda","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Urioste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191506"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00187-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90457-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2003.08.018"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(03)00204-8"},{"key":"e_1_2_1_7_2","first-page":"186","article-title":"An optimized multiplex polymerase chain reaction (PCR) for detection of BCR\u2010ABL fusion mRNAs in haematological disorders","volume":"8","author":"Cross NC","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(99)00131-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1182\/blood.V76.9.1812.1812","article-title":"Ph\u2010negative chronic myeloid leukemia: molecular analysis of ABL insertion into M\u2010BCR on chromosome 22","volume":"76","author":"Morris CM","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04007"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152171299"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:41:55Z","timestamp":1700030515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,6]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/hon.775"],"URL":"https:\/\/doi.org\/10.1002\/hon.775","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,6]]}}}