{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:31:49Z","timestamp":1789835509157,"version":"4.0.1"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T00:00:00Z","timestamp":1148428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravascular lymphoma (IVL) is an extremely rare form of non\u2010Hodgkin lymphoma characterized by almost exclusive growth of neoplastic lymphocytes within blood vessel lumen. IVL is morphologically characterized in most instances by large cells with B\u2010cell lineage. IVL is an aggressive and usually disseminated disease that predominantly affects elderly patients, resulting in poor PS, B\u2010symptoms, anemia, and high lactate dehydrogenase serum level. The brain and skin are the most commonly involved sites; nodal disease is rare. Survival after conventional chemotherapy is disappointing, with a relevant impact of diagnostic delay and lethal complications.<\/jats:p><jats:p>Notwithstanding these results, IVL limited to the skin (cutaneous variant) is a favorable presentation with distinctive clinical characteristics. Moreover, differences in clinical presentation with Eastern Countries IVL cases, mostly associated with hemophagocytic syndrome, do exist. Intensive combinations containing drugs with higher central nervous system bioavailability are needed in cases with brain involvement; the role of high\u2010dose chemotherapy with autologous stem cell transplantation should be investigated in younger patients with unfavorable features. The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic\/biologic characteristics as well as clinical\/therapeutic issues of IVL. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.776","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T12:12:42Z","timestamp":1148472762000},"page":"105-112","source":"Crossref","is-referenced-by-count":108,"title":["Intravascular lymphoma: a neoplasm of \u2018homeless\u2019 lymphocytes?"],"prefix":"10.1002","volume":"24","author":[{"given":"Maurilio","family":"Ponzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J. M.","family":"Ferreri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,24]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"359","article-title":"On the recognition of systematized endotheliomatosis of the cutaneous blood vessels (reticuloendotheliosis?","volume":"10","author":"Pfleger L","year":"1959","journal-title":"Hautarzt"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604103141502"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_1_5_2","first-page":"177","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues","author":"Gatter KC","year":"2001"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)66:8<1781::AID-CNCR2820660824>3.0.CO;2-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930515)71:10<3156::AID-CNCR2820711043>3.0.CO;2-O"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.12.2573"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05177.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02426.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.033662"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007809"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900070303"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01378-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008413.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80223-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20300"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800156"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800297"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0080-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880450"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20253"},{"issue":"4","key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5858\/1999-123-0335-AILCLO","article-title":"Angiotropic (intravascular) large cell lymphoma of T\u2010cell phenotype presenting as acute appendicitis in a patient with acquired immunodeficiency syndrome","volume":"123","author":"Malicki DM","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11107"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1309\/X597G3QMXAFBCM5V"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0948-MPILBC"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000132743.89349.35"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80500-8"},{"issue":"5","key":"e_1_2_1_29_2","first-page":"593","article-title":"Intravascular (angiotropic) large cell lymphoma: determination of monoclonality by polymerase chain reaction on paraffin\u2010embedded tissues","volume":"7","author":"Sleater JP","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100398"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02013.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200204000-00015"},{"issue":"6","key":"e_1_2_1_33_2","first-page":"444","article-title":"Intravascular lymphomatosis (malignant angioendotheliomatosis). A B\u2010cell neoplasm expressing surface homing receptors","volume":"1","author":"Ferry JA","year":"1988","journal-title":"Mod Pathol"},{"issue":"6","key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1182\/blood.V92.6.2182","article-title":"Detection of antibodies to Fasciola and Anisakis in Japanese patients with intravascular lymphomatosis","volume":"92","author":"Murase T","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90044-P"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.3050903.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199904000-00015"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800397"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.3.439"},{"issue":"2","key":"e_1_2_1_40_2","first-page":"239","article-title":"Angiotropic large cell lymphoma with imaging characteristics of CNS vasculitis","volume":"23","author":"Song DK","year":"2002","journal-title":"Am J Neuroradiol"},{"issue":"2","key":"e_1_2_1_41_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ajcp\/83.2.244","article-title":"Malignant angioendotheliomatosis: an angiotropic lymphoma?","volume":"83","author":"Wrotnowski U","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.3.403"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940315)73:6<1738::AID-CNCR2820730631>3.0.CO;2-U"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000268"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.7636"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90379-2"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199610)53:2<144::AID-AJH18>3.0.CO;2-F"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.5.1199"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.3310898.x"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199805000-00015"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.1207"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.9.869"},{"issue":"6","key":"e_1_2_1_53_2","first-page":"580","article-title":"Primary hepatic lymphoma presenting as intravascular lymphomatosis","volume":"114","author":"Kayano H","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199711)56:3<155::AID-AJH4>3.0.CO;2-X"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850201)55:3<570::AID-CNCR2820550316>3.0.CO;2-0"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198602000-00004"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1506::AID-CNCR2820500810>3.0.CO;2-3"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199707000-00016"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2260835.x"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.10.787"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20288"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00311-9"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703038"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.2.219-a"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh274"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909058451"},{"issue":"7","key":"e_1_2_1_67_2","first-page":"542","article-title":"Lymphoma\u2010associated hemophagocytic syndrome in Japan","volume":"40","author":"Takahashi N","year":"1999","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009060325"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089169708300412"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.3.374"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001215)89:12<2515::AID-CNCR1>3.0.CO;2-H"},{"issue":"5","key":"e_1_2_1_72_2","first-page":"975","article-title":"Intravascular lymphomatosis presenting as bilateral adrenal enlargement and insufficiency","volume":"43","author":"Kuwabara H","year":"1999","journal-title":"Acta Cytol"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(98)00074-2"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911115)68:10<2319::AID-CNCR2820681035>3.0.CO;2-9"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(98)00083-6"},{"issue":"2","key":"e_1_2_1_76_2","first-page":"137","article-title":"Regression of cutaneous intravascular lymphoma with rituximab","volume":"72","author":"Han K","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02444016"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<474::AID-CNCR2820660313>3.0.CO;2-P"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006476701534"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.640"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702735"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.1368a.x"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80166-1"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.4623265.x"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf214"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01613.x"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.776","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T07:27:36Z","timestamp":1700033256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,24]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/hon.776"],"URL":"https:\/\/doi.org\/10.1002\/hon.776","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,24]]}}}