{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:30:39Z","timestamp":1779121839727,"version":"3.51.4"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas (PTCL) have been difficult to classify. A homogeneous principle of classification is still lacking, partly because lymph node compartments containing functionally distinct T\u2010cell subsets have not been identified. A correlation to differentiated T\u2010cell subsets, as CD4<jats:sup>+<\/jats:sup> or CD8<jats:sup>+<\/jats:sup> cells as well as cytotoxic populations has not revealed clinically meaningful entities. Upon antigen encounter, mature T\u2010cells pass through distinct stages characterized by their surface molecule expression. Na\u00efve T\u2010cells are CD45RA<jats:sup>+<\/jats:sup>\/CD45R0<jats:sup>\u2212<\/jats:sup>\/CD27<jats:sup>+<\/jats:sup>\/CCR7<jats:sup>+<\/jats:sup>, however, after antigen contact CD45RA expression is replaced by CD45R0. They differentiate to central memory cells, which retain CD27 and CCR7, or to effector\u2010memory cells, which loose expression of both molecules depending on the strength of the antigen interaction. Immunohistological analysis of PTCL showed an effector or effector\u2010memory cell phenotype (CD45RA<jats:sup>\u2212<\/jats:sup>\/CD45R0<jats:sup>+<\/jats:sup>\/CD27<jats:sup>\u2212<\/jats:sup>) for both angioimmunoblastic T\u2010cell lymphoma (AILT) and anaplastic large cell lymphoma (ALCL), but different cytotoxic and activation markers expressed by these tumours. A subset of CD4<jats:sup>+<\/jats:sup> PTCL\u2010not otherwise specified (PTCL\u2010NOS) may correspond to a central memory cell phenotype (CD45RA<jats:sup>\u2212<\/jats:sup>\/CD45R0<jats:sup>+<\/jats:sup>\/CD27<jats:sup>+<\/jats:sup>). Thus, a correlation of PTCL to stages of differentiation, rather than to the direction of differentiation, may reveal homogeneous categories. A comparison between the lymphomas and their normal counterparts maycontribute to the understanding of the underlying transformation mechanisms. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.786","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T10:37:38Z","timestamp":1150713458000},"page":"175-180","source":"Crossref","is-referenced-by-count":41,"title":["\u2018Normal counterparts\u2019 of nodal peripheral T\u2010cell lymphoma"],"prefix":"10.1002","volume":"24","author":[{"given":"Thomas","family":"R\u00fcdiger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Geissinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Konrad","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"e_1_2_1_3_2","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097644"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90367-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb01451.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.7837"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90148-X"},{"key":"e_1_2_1_9_2","first-page":"181","article-title":"Immunophenotypic criteria for the diagnosis of non\u2010Hodgkin's lymphoma","volume":"128","author":"Picker LJ","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500205"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00128.x"},{"key":"e_1_2_1_12_2","first-page":"396","article-title":"Phenotypic analysis of peripheral T cell lymphoma among the Japanese","volume":"43","author":"Nakamura S","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<432::AID-PATH942>3.0.CO;2-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4501"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90299-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1077-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1820102.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.09.002"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0701"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1206"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1083"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_1_23_2","first-page":"275","article-title":"Assigning the phenotype of a natural regulatory T\u2010cell to the human T\u2010cell line, KARPAS\u2010299","volume":"17","author":"Wolke C","year":"2006","journal-title":"Int J Mol Med"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403965"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2181"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.17717.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0200184"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/360264a0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220418"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.5.2426"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.7.1027"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1407"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5538"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.593"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.381"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.1053"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-379"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6675"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.2.685"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.10.3487.410k39_3487_3493"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10758"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.297"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199910000-00003"},{"key":"e_1_2_1_47_2","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood.V72.3.1000.bloodjournal7231000","article-title":"Clinicopathologic, immunophenotypic, and immunogenotypic analyses of immunoblastic lymphadenopathy\u2010like T\u2010cell lymphoma","volume":"72","author":"Tobinai K","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_48_2","first-page":"141","article-title":"Peripheral T\u2010cell lymphoma of AILD (angioimmunoblastic lymphadenopathy with dysproteinemia) type involving gastrointestinal tract. A morphologic, phenotypic and genotypic study","volume":"42","author":"Nakamura S","year":"1992","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199806000-00001"},{"key":"e_1_2_1_50_2","first-page":"1093","article-title":"Epstein\u2010Barr virus in a CD8\u2010positive T\u2010cell lymphoma","volume":"136","author":"Richel DJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.2.474.474"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193945"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1991.tb01550.x"},{"key":"e_1_2_1_54_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/blood.V72.2.413.413","article-title":"Characteristic karyotypic pattern in T\u2010cell lymphoproliferative disorders with reactive \u2018angioimmunoblastic lymphadenopathy with dysproteinemia\u2010type\u2019 features","volume":"72","author":"Kaneko Y","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02290.x"},{"key":"e_1_2_1_56_2","first-page":"549","article-title":"Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy","volume":"133","author":"Feller AC","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.50.1.15"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.2.152"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06937.x"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(96)00021-1"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb01326.x"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60576-4"},{"key":"e_1_2_1_63_2","first-page":"605","article-title":"Classification of distinct subtypes of peripheral T\u2010cell lymphoma unspecified, identified by chemokine and chemokine receptor expression: analysis of prognosis","volume":"25","author":"Ohshima K","year":"2004","journal-title":"Int J Oncol"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209178"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1352"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0269"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70213-8"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0371"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00051.x"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00022.x"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3513.bloodjournal8893513"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01444-9"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1037"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.786","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:46:35Z","timestamp":1700027195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,19]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/hon.786"],"URL":"https:\/\/doi.org\/10.1002\/hon.786","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,19]]}}}