{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:32Z","timestamp":1790740052404,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the clinico\u2010pathologic features and treatment outcome of patients with peripheral T\u2010cell lymphoma (PTCL). This study included 215 patients with T\/natural killer (NK)\u2010cell lymphoma, including 59 with PTCL\u2010unspecified (PTCL\u2010U), 42 with angioimmunoblastic T\u2010cell lymphoma (AILT) and 20 with anaplastic large\u2010cell lymphoma (ALCL). Most of the analyses were performed on patients with AILD, ALCL and PTCL\u2010U. The patients with AILT and PTCL\u2010U tended to be older than those with ALCL. Stage III\/IV disease was seen in 90.5% of the AILT cases, 55% of the ALCL cases and 67.8% of the PTCL\u2010U cases. In addition, 61.9% of the AILT cases had an international prognostic index (IPI) of H\u2010I or H risk. The 5\u2010year progression\u2010free survival (PFS) and overall survival (OS) rates were 72.2 and 76.1% among the ALCL cases, 40.7 and 42.2% among the PTCL\u2010U cases and 31.2 and 49.3% among the AILT cases, respectively. Among the patients with PTCL\u2010U, the 5\u2010year PFS and OS rates in group low (L), low\u2010intermediate (L\u2010I), high\u2010intermediate (H\u2010I) or high (H) risk group of IPI were: 47.6 and 56.1%, 55.6 and 53.8%, 42.4 and 40.1% and 9.1 and 9.1%, respectively. The 5\u2010year PFS and OS rates in group 1, 2, 3 or 4 by prognostic index of PTCL\u2010U (PIT) were: 88.9 and 85.7%, 57.1 and 54.9%, 33.5 and 28.8% or 13.3 and 13.3%, respectively. The 5\u2010year PFS and OS rates among patients who received CHOP therapy, CyclOBEAP [cyclophosphamide (CPA), vincristine (VCR), bleomycine, etoposide, doxorubicin (DXR), prednisone (PDN)] therapy or autologous stem cell transplantation were: 22 and 25.7%, 59 and 61.7% or 33.3 and 60%, respectively. Multivariate analysis revealed that the PIT score was associated with OS and PFS. These results indicate that the presence of bone marrow (BM) involvement is an independent prognostic factor which may predict both OS and PFS. PTCL\u2010U is a heterogeneous disease with regard to histological type and pathological state. Because PTCL\u2010U is generally not responsive to CHOP therapy, new treatment strategies need to be developed. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.853","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T10:16:26Z","timestamp":1207649786000},"page":"152-158","source":"Crossref","is-referenced-by-count":35,"title":["Clinico\u2010pathologic features and outcome of Japanese patients with peripheral T\u2010cell lymphomas"],"prefix":"10.1002","volume":"26","author":[{"given":"Nozomi","family":"Niitsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Nakamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_1_3_2","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. 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