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These proteins were significantly up\u2010regulated in neoplastic lymphocytes and a significantly higher expression of HIF1<jats:italic>\u03b1<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u20090.05), VEGF (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and pVEGFR2\/KDR (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) was recorded in diffuse large B\u2010cell lymphomas(DLBCL) compared to follicular lymphomas (FL). A strong statistical association of pVEGFR2\/KDR expression with high HIF1<jats:italic>\u03b1<\/jats:italic>, HIF2<jats:italic>\u03b1<\/jats:italic> and VEGF was noted in both DLBCL and FL. HIF1<jats:italic>\u03b1<\/jats:italic> andHIF2<jats:italic>\u03b1<\/jats:italic> were linked with VEGF expression but no association between HIF1<jats:italic>\u03b1<\/jats:italic> and HIF2<jats:italic>\u03b1<\/jats:italic> was noted. Vascular density was significantly higher in the lymphoma compared to normal tissue, but there was no association with any of the examined parameters. It is concluded that the VEGF\/receptor pathway is active in more than half of NHLs and particularly in DLBCL. The intimate correlation of VEGF production with the presence of phosphorylated VEGF\u2010receptors strongly supports the concept of an autocrine pathway. The strong association of HIF<jats:italic>\u03b1<\/jats:italic>s with the expression of VEGF and pVEGFR2\/KDR found in the study provide strong evidence on the role of HIF<jats:italic>\u03b1<\/jats:italic>s inthe activation of angiogenic and VEGF\u2010autocrine pathways that may be critical therapeutic targets for HIF\u2010inhibitors or other anti\u2010angiogenic agents. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.861","type":"journal-article","created":{"date-parts":[[2008,5,7]],"date-time":"2008-05-07T11:49:52Z","timestamp":1210160992000},"page":"219-224","source":"Crossref","is-referenced-by-count":26,"title":["Phosphorylated VEGFR2\/KDR receptors are widely expressed in B\u2010cell non\u2010Hodgkin's lymphomas and correlate with hypoxia inducible factor activation"],"prefix":"10.1002","volume":"26","author":[{"given":"Alexandra","family":"Giatromanolaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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