{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:46:09Z","timestamp":1776987969248,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T00:00:00Z","timestamp":1235606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>B\u2010cell chronic lymphocytic leukaemia (B\u2010CLL) is a heterogeneous disease with some patients having an indolent course never needs treatment, while others having rapidly progressive one requires intensive treatment. In recent decades, numerous prognostic markers, such as immunoglobulin variable region heavy\u2010chain (IgVH) mutational status, ZAP\u201070 and the expression of CD38 on leukaemic cells were introduced to screen for patients likely to have progressive course of B\u2010CLL bearing the potential to facilitate risk\u2010adapted treatment strategies. In B\u2010CLL, T cell function is shown to be dysregulated. CD38 has been demonstrated to be an important transmembrane signalling molecule of T cell with a direct effect on its function. The present study was conducted to analyse CD38 expression on T cells by flow cytometry to evaluate its impact on the clinical course of 88 unselected B\u2010CLL patients and correlate it with other risk factors. CD38 expression level on T cells was shown to predict the clinical course of B\u2010CLL in male patients but not in female patients. Male patients showed CD38 expression on T cells in a stage\u2010dependent manner, in contrast to female patients who showed higher expression irrespective to clinical staging. CD38 expression on T cells negatively interacted with treatment\u2010free survival in male patients. Multivariate analysis revealed that CD38 expression level on T cells is an independent prognostic factor in B\u2010CLL male patients. Simultaneous evaluation of CD38 expression on both B\u2010CLL cells and T cells allowed predicting male patient groups with the most favourable prognosis as well as those with the worst. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.877","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T09:44:51Z","timestamp":1235641491000},"page":"82-89","source":"Crossref","is-referenced-by-count":8,"title":["T\u2010cell CD38 expression in B\u2010chronic lymphocytic leukaemia"],"prefix":"10.1002","volume":"27","author":[{"given":"Nashwa Khayrat","family":"Abousamra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal Salah","family":"EL\u2010Din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Azmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331606"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141018"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.2.219.219"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V"},{"key":"e_1_2_1_6_2","first-page":"587","article-title":"Novel therapies for chronic lymphocytic leukemia in the 21st century","volume":"27","author":"Byrd JC","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_1_7_2","first-page":"42","article-title":"Chronic lymphocytic leukemia: staging and prognostic factors","volume":"25","author":"Zwiebel JA","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated IgV (H) genes are associated with a more aggressive form lymphocytic leukemia","volume":"94","author":"Hamblin TJ","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2007.02.001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"IgV gene mutation status and CD38 expression as a novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle RN","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.1023"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.1.181"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097682"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1182\/blood.V100.4.1177.h81602001177_1177_1184","article-title":"Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of p53 gene are independent prognostic factors","volume":"100","author":"Oscier DG","year":"2002","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1182\/blood.V100.4.1410.h81602001410_1410_1416","article-title":"VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia","volume":"100","author":"Kr\u00f6ber A","year":"2002","journal-title":"Blood"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2001.3205.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403907"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000029993"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90148-1"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.8.2390"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-010553"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/cdli.3.1.30-36.1996","article-title":"Multiparametric immunophenotyping of B cells in peripheral blood of healthy adults by flowcytometry","volume":"3","author":"H\u00f6ffkes HG","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","article-title":"National cancer institute sponsored working group guideline for chronic lymphocytic leukemia: revised guideline for diagnosis and treatment","volume":"87","author":"Cheson BD","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi731"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023143"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj120"},{"key":"e_1_2_1_27_2","volume-title":"Statistical Methods in Medical Research","author":"Armitage P","year":"1987"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.10.007"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(02)00055-7"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/62380"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.10.861"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2281"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"9a","DOI":"10.1182\/blood.V104.11.16.16","article-title":"In chronic lymphocytic leukemia females survive for longer than males even in patients with unmutated immunoglobulin genes [abstract]","volume":"104","author":"Hamblin T","year":"2004","journal-title":"Blood"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600555819"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1200\/jco.2007.25.18_suppl.7090","article-title":"Improved risk assessment in B\u2010cell chronic lymphocytic leukemia based on sex\u2010specific molecular profiling [abstract]","volume":"25","author":"Tinhofer I","year":"2007","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001286"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.057"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0499"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.877","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T18:34:39Z","timestamp":1699900479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,26]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/hon.877"],"URL":"https:\/\/doi.org\/10.1002\/hon.877","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,26]]}}}