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Literature data are presented on first line curative irradiation in stage I and II patients, low\u2010dose total body irradiation (TBI) in stage III and IV patients in first line and low\u2010dose IF\u2010RT (involved field radiotherapy) in patients with relapse. The clinical aspects of 2\u2009\u00d7\u20092\u2009Gy IF\u2010RT in follicular lymphoma (FL) are presented as well as the <jats:italic>in vivo<\/jats:italic> imaging of the apoptotic cell death underlying the clinical response. Finally, by gene expression profiling, possible molecular\u2010biological pathways are described involved in the low dose irradiation of FL. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.882","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T08:18:16Z","timestamp":1236241096000},"page":"71-81","source":"Crossref","is-referenced-by-count":20,"title":["Low dose radiotherapy in indolent lymphomas, enough is enough"],"prefix":"10.1002","volume":"27","author":[{"given":"R. L. 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