{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:42:07Z","timestamp":1778557327359,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt Lymphoma (BL) is listed in the World Health Organization (WHO) classification of lymphoid tumours as an \u201caggressive B\u2010cell non\u2010Hodgkin's lymphoma\u201d, characterized by a high degree of proliferation of the malignant cells and deregulation of the c\u2010<jats:italic>MYC<\/jats:italic> gene. The main diagnostic challenge in BL is to distinguish it from diffuse large B\u2010cell lymphoma (DLBCL). While in children BL and DLBCL types probably do not differ clinically, and the differential diagnosis between BL and DLBCL may theoretically appear clear\u2010cut, in adults daily practice shows the existence of cases that have morphological features, immunophenotypic and cytogenetics intermediate between DLBCL and BL, and cannot be classified with certainty in these categories. Distinguishing between BL and DLBCL is critical, as the two diseases require different management. This review summarizes the current practical approach, including the use of a large panel of antibodies, and cytogenetic and molecular diagnostic techniques, to distinguish between BL, DLBCL and the provisional category of \u201cB\u2010cell lymphoma, unclassificable, with features intermediate between diffuse large B\u2010cell lymphoma and Burkitt lymphoma\u201d, now listed in the updated WHO classification. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.914","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T11:19:55Z","timestamp":1249989595000},"page":"182-185","source":"Crossref","is-referenced-by-count":30,"title":["Burkitt lymphoma versus diffuse large B\u2010cell lymphoma: a practical approach"],"prefix":"10.1002","volume":"27","author":[{"given":"Cristiana","family":"Bellan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazzi","family":"Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De Falco","family":"Giulia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily A.","family":"Rogena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leoncini","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. 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