{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:46:20Z","timestamp":1793108780904,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixty\u2010six B\u2010cell lymphoma patients were treated with a CHOP\u2010based chemotherapy containing rituximab (R\u2010CHOP\u2010like regimen). Immune reconstitution was assessed by measuring lymphocyte subsets and immunoglobulins. Fifty\u2010five patients (83.3%) underwent six cycles of the R\u2010CHOP\u2010like regimen. CD19<jats:sup>+<\/jats:sup> and CD20<jats:sup>+<\/jats:sup> cells were completely eliminated from the peripheral blood after one cycle of the R\u2010CHOP\u2010like regimen; they were detected again 6 months after the therapy. One year after the therapy, B\u2010cell numbers recovered to their level at diagnosis and almost doubled 2 years after the therapy. The lowest numbers of CD3<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup> and CD56<jats:sup>+<\/jats:sup> cells were seen after three cycles of the regimen, but continued to increase until 1 year after the therapy, remaining stable thereafter. CD4<jats:sup>+<\/jats:sup> T\u2010cells were at their lowest after six cycles of the regimen and recovered slowly for 2 years after the therapy; however, their numbers were still lower than that at diagnosis. Immunoglobulins decreased over six cycles of the R\u2010CHOP\u2010like regimen and then recovered gradually for 2 years after the therapy. The percentage of IgG, IgA and IgM 2 years after the therapy compared with those at diagnosis was 93.9%, 90.1%, 76.3%, respectively. Twelve infectious complications occurred which consisted of three febrile neutropenia, three Herpes Zoster, two tympanitis, two <jats:italic>Pneumocystis jiroveci<\/jats:italic> pneumonia and two hepatitis B virus reactivation. B\u2010cells required 1 year and CD4<jats:sup>+<\/jats:sup> T\u2010cells and immunoglobulins needed 2 years to recover after the therapy. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.947","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T07:07:37Z","timestamp":1276585657000},"page":"5-9","source":"Crossref","is-referenced-by-count":31,"title":["Immune reconstitution of B\u2010cell lymphoma patients receiving CHOP\u2010based chemotherapy containing rituximab"],"prefix":"10.1002","volume":"29","author":[{"given":"Toshiro","family":"Kurokawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Hase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Tokuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.389"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.133"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4278"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1484::AID-CNCR2820380407>3.0.CO;2-I"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.03147"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.10.3266"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2825"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.164"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21264"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp484"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1257"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705463"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.05.024"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001714052"},{"key":"e_1_2_5_21_2","first-page":"496","article-title":"Dose\u2010dense R\u2010CHOP\u201014 supported by pegfilgrastim in patients with diffuse large B\u2010cell lymphoma: a phase II study of feasibility and toxicity","volume":"91","author":"Brusamolino E","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0066-7"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.015"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0182"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.947","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:39:10Z","timestamp":1700595550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/hon.947"],"URL":"https:\/\/doi.org\/10.1002\/hon.947","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}