{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:08:41Z","timestamp":1771924121054,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T00:00:00Z","timestamp":1280966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010random karyotypic abnormalities associated with non\u2010Hodgkin lymphomas (NHLs) have been described in cases of reactive lymphoid hyperplasia (RLH). However, the frequency and types of cytogenetic aberrations detected and their clinical relevance are unknown. To address these questions, we undertook a retrospective analysis of a large series of RLH diagnosed at our institute over 8\u2009years. Cytogenetic abnormalities were identified in 20 of 116 (17%) cases with informative karyotypes, comprising 14 (70%) structural and 11 (55%) numerical changes. Clonal (<jats:italic>n<\/jats:italic>\u2009=\u200914, 70%) and non\u2010clonal (<jats:italic>n<\/jats:italic>\u2009=\u20096, 30%) abnormalities were observed. Aberrations of chromosome 14 were the most frequent (<jats:italic>n<\/jats:italic>\u2009=\u20098, 42%, 7 represented IgH translocations), followed by chromosome 3 (<jats:italic>n<\/jats:italic>\u2009=\u20094, 3 represented BCL6 translocations), and chromosome 12 (<jats:italic>n<\/jats:italic>\u2009=\u20094). Abnormal karyotypes were most often associated with florid follicular hyperplasia. Isolated lymphoid organ (lymph node, tonsil or spleen) enlargement (12\/20, 60%) was more common, no specific etiology was identified in 10\/20 (50%) cases and only 1 of 18 patients with clinical follow\u2010up (range 2\u2013107\u2009months, median 60\u2009months) developed lymphoma. In our experience, cytogenetic abnormalities involving loci associated with B\u2010cell NHL are not infrequently detected in RLH. Their occurrence portends low risk for lymphomagenesis, however longer follow\u2010up is prudent to further evaluate the natural history of such cases. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.958","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T19:25:36Z","timestamp":1281036336000},"page":"81-90","source":"Crossref","is-referenced-by-count":17,"title":["Cytogenetic abnormalities in reactive lymphoid hyperplasia: byproducts of the germinal centre reaction or indicators of lymphoma?"],"prefix":"10.1002","volume":"29","author":[{"given":"Deborah W.","family":"Sevilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vundavalli V.","family":"Murty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Lai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhadra V.","family":"Nandula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh M.","family":"Mansukhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar68"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01472-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040437"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3277"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200009000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/78.3.316"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/4EJ8T3R2ERKQ61WH"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200307000-00002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309148511"},{"key":"e_1_2_5_11_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_12_2","first-page":"291","article-title":"Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients","volume":"141","author":"Aster JC","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-011536"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64690-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.8910"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1837.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3549"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440602"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1182\/blood.V69.3.855.855","article-title":"Chromosome abnormalities in AIDS\u2010associated lymphadenopathy","volume":"69","author":"Alonso ML","year":"1987","journal-title":"Blood"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10109"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90007-0"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.6.1876.1876"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90349-D"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870070309"},{"key":"e_1_2_5_26_2","volume-title":"An International System for Human Cytogenetic Nomenclature","author":"Shaffer L","year":"2009"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1182\/blood.V83.11.3271.3271","article-title":"Heteroduplex analysis of T\u2010cell receptor gamma gene rearrangements for diagnosis and monitoring of cutaneous T\u2010cell lymphomas","volume":"83","author":"Bottaro M","year":"1994","journal-title":"Blood"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199503000-00004"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3376"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402707"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.08.014"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.04.007"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199906)25:2<123::AID-GCC8>3.0.CO;2-4"},{"key":"e_1_2_5_34_2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1182\/blood.V84.4.1043.1043","article-title":"Prognostic value of chromosomal abnormalities in follicular lymphoma","volume":"84","author":"Tilly H","year":"1994","journal-title":"Blood"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1540"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00150-2"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1309\/UUEPLF2PHYXQDJNQ"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65742-2"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0300"},{"key":"e_1_2_5_40_2","first-page":"402","article-title":"Transplantation\u2010related lymphoproliferative disorder: a model for human immunodeficiency virus\u2010related lymphomas","volume":"27","author":"Swinnen LJ","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.01.009"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001593166"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1589"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001621588"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.3.808"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.03.037"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2469"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/349254a0"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11011"},{"key":"e_1_2_5_50_2","first-page":"24","article-title":"Clinical implications of nodal reactive follicular hyperplasia in the elderly patient with enlarged lymph nodes","volume":"4","author":"Osborne BM","year":"1991","journal-title":"Mod Pathol"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404482"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.958","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:37:06Z","timestamp":1700595426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1002\/hon.958"],"URL":"https:\/\/doi.org\/10.1002\/hon.958","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}