{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T03:59:04Z","timestamp":1754193544412},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiotoxicity has been feared as a potential side effect of imatinib therapy. Studies with short\u2010term follow\u2010up failed to identify an excess of cardiac events, but longer\u2010term observations are needed to more definitely exclude this adverse effect. This study was designed to assess the cardiac effects of imatinib in patients under long\u2010term treatment. We included 90 chronic myeloid leukaemia (CML) patients under imatinib therapy for a median treatment time of 3.3\u2009years (mean age 48.9\u2009\u00b1\u200915.1\u2009years). Patients underwent clinical evaluation, electrocardiography, echocardiography (two\u2010dimensional, colour flow, tissue Doppler and strain imaging), brain natiuretic peptide (BNP) and troponin I measurements. Twenty healthy volunteers were included as a control group for strain measurements. The mean ejection fraction was 68\u2009\u00b1\u20097% and the median BNP level was 9.6\u2009pg\/ml (interquartile range [IQR] 5.7\u201317.0\u2009pg\/ml). Two patients had either an elevated BNP or a depressed ejection fraction (2.2%; 90%CI 0.9\u20136.8%). Most of troponin I measurements were lower than the detection limit, except for two patients. Longitudinal strain was similar to measurements in healthy controls. A weak relation was observed between log BNP and imatinib treatment duration and dose. There was no relation between these variables and left ventricle ejection fraction. In conclusion, matinib\u2010related cardiotoxicity is an uncommon event in CML patients, even during long\u2010term treatment. Therefore, its use should not be cause of great concern, and the usefulness of regular cardiac monitoring all patients while on imatinib therapy is questionable. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.967","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T13:19:11Z","timestamp":1285161551000},"page":"124-130","source":"Crossref","is-referenced-by-count":13,"title":["The duration of the use of imatinib mesylate is only weakly related to elevated BNP levels in chronic myeloid leukaemia patients"],"prefix":"10.1002","volume":"29","author":[{"given":"Milena S.","family":"Marcolino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelma C.D.","family":"Clementino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo P.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia M.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena C.R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel L.","family":"Geleijnse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0779"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/434761"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441402"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1824"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.11.004"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1446"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.11.014"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.08.016"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.018"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.03.020"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.07.006"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-070144"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.01.018"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0107-15a"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21157"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm468"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.07.011"},{"key":"e_1_2_7_19_2","unstructured":"O'BrienS BermanE BorghaeiH et al. National Comprehensive Cancer Network\u00ae (NCCN). Practice Guidelines in Oncology\u2122: Chronic Myelogenous Leukemia Version 2.2010.2009. Available at:http:\/\/www.nccn.org\/"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0183"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61165-9"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.189141"},{"key":"e_1_2_7_23_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders\u2014DSM IV","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_24_2","volume-title":"Clinical Electrocardiography: A Textbook","author":"Bayes de Luna A","year":"1998"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.2.212"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00345-3"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00344-6"},{"key":"e_1_2_7_29_2","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1067\/j.echo.2003.09.004","article-title":"Clinical applications of strain rate imaging","volume":"16","author":"Yip G","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.061"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.06.019"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2007.12.007"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01744-2"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.021"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61865-0"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860903229124"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.967","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:34:32Z","timestamp":1700595272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,22]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/hon.967"],"URL":"https:\/\/doi.org\/10.1002\/hon.967","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,22]]}}}