{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:27:32Z","timestamp":1762079252446},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radioimmunotherapies with Zevalin\u00ae (RIT\u2010Z) showed encouraging results in patients with relapsed\/refractory follicular lymphoma (FL), leading frequently to failure\u2010free intervals longer than those achieved by the last previous therapy. We compared time\u2010to\u2010event variables obtained before and after RIT\u2010Z in patients with relapsed FL, previously exposed to rituximab. All patients with relapsed non\u2010transformed, non\u2010refractory, non\u2010rituximab\u2010na\u00efve FL who have been treated with RIT\u2010Z in two different centres in Europe were included. Staging and response were assessed by contrast\u2010enhanced CT in all patients; PET\/CT was performed according to local availability. Event\u2010free survival (EFS) and time to next treatment (TTNT) following the last previous therapy and after RIT\u2010Z were compared. Pre\u2010therapy characteristics were tested in univariate analyses for prediction of outcomes. A description of the patterns of relapse was also provided. Among 70 patients treated, only 16 fulfilled the inclusion criteria. They were treated with a median of 3 prior lines of chemo\u2010immunotherapies, including a median of 2 rituximab\u2010containing regimens; 6 patients had undergone myeloablative chemotherapy with autologous stem cell rescue (ASCT). Overall response rates were 10 (62%) CR\/CRu, 3 (19%) PR and 3 (19%) PD; response rates were similar in patients with prior ASCT. After RIT\u2010Z only few patients obtained EFS and TTNT longer than after the last previous therapy. All four patients receiving rituximab maintenance were without progression 12 months after RIT\u2010Z. Relapses occurred in both previously and newly involved sites; a significant association was found between the number of pathologic sites involved prior to RIT\u2010Z and subsequent TTNT. Despite the excellent response rate, the duration of response was shorter than the previous one confirming the known trend of relapses to occur earlier after subsequent treatments. Rituximab maintenance after RIT\u2010Z showed encouraging results in terms of prolonging EFS, warranting further studies. 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