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However, the current knowledge indicates that it is also a useful prognostic tool in several mature lymphoproliferative disorders. Its utility is currently well established in follicular lymphoma, mantle cell lymphoma, and multiple myeloma. In some of these entities, clinical trials employing MRD as a decision\u2010making tool are currently ongoing. In the present review, we will discuss the \u2018state of the art\u2019 of MRD evaluation in these three neoplasms with the ultimate aim of providing critical take\u2010home messages for clinicians working in the field. Moreover, we will outline the role of MRD detection in the design of future clinical trials. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hon.989","type":"journal-article","created":{"date-parts":[[2011,4,2]],"date-time":"2011-04-02T04:51:34Z","timestamp":1301719894000},"page":"167-176","source":"Crossref","is-referenced-by-count":34,"title":["Minimal residual disease detection in lymphoma and multiple myeloma: impact on therapeutic paradigms"],"prefix":"10.1002","volume":"29","author":[{"given":"Simone","family":"Ferrero","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Experimental Medicine and Oncology University of Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Drandi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Experimental Medicine and Oncology University of Torino Turin 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