{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:16:22Z","timestamp":1764519382040,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Planning &amp; Management"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nowadays, the use of food supplements has increased globally. Among them, there are also plant\u2010based supplements that contain phytochemical extracts with a pharmacological effect and consequently potential adverse reactions. We cannot estimate their safety profile as there are not required evidence\u2010based proofs before marketing. Though European Food Safety Authority is responsible for the risks derived from food supplements, there is not any centralized surveillance system of the commercialized supplements in Europe. Moreover, these products do not rely on a harmonised marketing legislation. The population is exposed unconsciously purchasing them in internet or other places that lack of a professional healthcare. Fragile subgroups like pregnant women, patients with concomitant therapies, are not aware of the risks of plant\u2010based supplements because the education strategies are not promoted enough. In the context of public health, the challenge is to implement measures in order to protect consumers against health risks. Future efforts are required to ensure standardised supplements. European regulatory programs should be harmonised. More clinical trials and toxicological studies should be conducted on commercial preparations. Accurate information sources could assure consumers about the correct use of botanicals.<\/jats:p>","DOI":"10.1002\/hpm.3177","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T04:07:25Z","timestamp":1619150845000},"page":"1370-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The safety concern of plant\u2010based supplements: A public health topic"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-951X","authenticated-orcid":false,"given":"Olta","family":"Allkanjari","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"European Food Safety Authority.https:\/\/www.efsa.europa.eu\/it\/topics\/topic\/botanicals. 2021 Accessed February 13 2021."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010617-052844"},{"key":"e_1_2_5_4_1","unstructured":"FederSalus Research Centre.5th Industry survey. The Italian Food Supplement Supply Chain 2019\u20102020.https:\/\/www.federsalus.it\/wp\u2010content\/uploads\/2020\/06\/Report_5th\u2010Industry\u2010survey\u20103.pdf. 2020 Accessed February 20 2021."},{"key":"e_1_2_5_5_1","unstructured":"European Medicines Agency.https:\/\/www.ema.europa.eu\/en\/human\u2010regulatory\/herbal\u2010medicinal\u2010products. 2021 Accessed February 13 2021."},{"issue":"8","key":"e_1_2_5_6_1","first-page":"e05368","article-title":"Scientific opinion on the safety of monacolins in red yeast rice","volume":"16","author":"EFSA Panel Food Additives and Nutrient Sources added to Food","year":"2018","journal-title":"EFSA J"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2018.5090"},{"key":"e_1_2_5_8_1","unstructured":"Commission Regulation ( EU ) 2021\/468 of 18 March 2021 amending Annex III to Regulation (EC) No 1925\/2006 of the European Parliament and of the Council as regards botanical species containing hydroxyanthracene derivatives."},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104818"},{"key":"e_1_2_5_10_1","unstructured":"Regulation (EC) No 1925\/2006 of the European Parliament and of the Council of 20 December 2006 on the addition of vitamins and minerals and of certain other substances to foods."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2019.0128"},{"issue":"4","key":"e_1_2_5_12_1","first-page":"462","article-title":"Turmeric (Curcuma longa L.) food supplements and hepatotoxicity: an integrated evaluation approach","volume":"56","author":"Menniti\u2010Ippolito F","year":"2020","journal-title":"Ann Ist Super Sanita"},{"issue":"1","key":"e_1_2_5_13_1","first-page":"1","article-title":"The use of herbal products during pregnancy: which is the risk perception?","volume":"9","author":"Vitalone A","year":"2021","journal-title":"Am J Phytomed Clin Ther"}],"container-title":["The International Journal of Health Planning and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpm.3177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hpm.3177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpm.3177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:05:10Z","timestamp":1693350310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hpm.3177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/hpm.3177"],"URL":"https:\/\/doi.org\/10.1002\/hpm.3177","archive":["Portico"],"relation":{},"ISSN":["0749-6753","1099-1751"],"issn-type":[{"type":"print","value":"0749-6753"},{"type":"electronic","value":"1099-1751"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"2021-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}