{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:06:22Z","timestamp":1791860782406,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Major depressive disorder (MDD) is the fourth biggest health\u2010related concern that dramatically impacts individuals' mental and physical health. Alteration of serum proinflammatory cytokine levels may take part in the development and progression of MDD. We aimed to explore and compare the role of interleukin\u201012 (IL\u201012) in MDD patients and healthy controls (HCs) and its involvement with the disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 85 patients and 87 age\u2010sex matched HCs. A qualified psychiatrist utilized the diagnostic and statistical manual of mental disorders, fifth edition (DSM\u20105) criteria to diagnose patients and evaluate HCs. We applied the Ham\u2010D rating scale to measure the severity of depression. Serum IL\u201012 levels were measured using ELISA kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a notable increase in the serum levels of IL\u201012 in MDD patients compared to HCs (164.27\u2009\u00b1\u200910.18\u2009pg\/ml and 82.55\u2009\u00b1\u20094.40\u2009pg\/ml; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Moreover, we noticed a positive correlation between serum IL\u201012 levels and Ham\u2010D scores in MDD patients (<jats:italic>r<\/jats:italic>\u2009=\u20090.363; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Receiver operating characteristic\u00a0analysis showed a good predictive performance (AUC\u2009=\u20090.871; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)\u00a0at the cut\u2010off point of 53.46\u2009pg\/ml for serum IL\u201012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study findings support that IL\u201012 levels are involved with the pathogenesis and inflammatory process in MDD. At the same time, this involvement may make this cytokine eligible for the risk evaluation of MDD. However, we recommend further interventional studies to explore more accurate associations between IL\u201012 and depressive disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1005","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T13:04:20Z","timestamp":1671887060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Higher serum interleukin\u201012 levels are associated with the pathophysiology of major depressive disorder: A case\u2010control study results"],"prefix":"10.1002","volume":"6","author":[{"given":"Zabun","family":"Nahar","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisat","family":"Sal\u2010Sabil","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-2284","authenticated-orcid":false,"given":"Md.","family":"Sohan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MMA Shalahuddin","family":"Qusar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-3144","authenticated-orcid":false,"given":"Md. Rabiul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.65"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318148c19a"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264404"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3167"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07495-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-04952-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120974169"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002743"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.027"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001511"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-90"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.36"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.137"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02738-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.36"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.98"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.50"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.02.133"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.33"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32834b9db6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102504"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113568"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.04.021"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14636"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.495"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.5.1387"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)80003-8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1997.0084"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001343"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00025"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02786451"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.03.015"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/76396"},{"issue":"5","key":"e_1_2_12_37_1","first-page":"4195","article-title":"Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta\u2010analysis","volume":"55","author":"K\u00f6hler CA","year":"2017","journal-title":"Mol Neurobiol"},{"key":"e_1_2_12_38_1","first-page":"135","article-title":"Inflammation and depression. curr top","volume":"14","author":"Zunszain PA","year":"2013","journal-title":"Behav Neurosci"},{"issue":"12","key":"e_1_2_12_39_1","article-title":"Evaluation of serum lysophosphatidic acid and lysophosphatidylcholine levels in major depressive disorder patients","volume":"12","author":"Riya S","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15020152"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045727"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2022.100320"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.807474"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.795"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2021.107506"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2021.107347"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211026409"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00304-5"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.03.004"},{"key":"e_1_2_12_50_1","doi-asserted-by":"crossref","unstructured":"PromaMA DariaS NaharZ Ashraful IslamSM BhuiyanMA IslamMR. Monocyte chemoattractant protein\u20101 levels are associated with major depressive disorder.\u00a0J Basic Clin Physiol Pharmacol.\u00a0Published online Jnauary 5 2022.doi:10.1515\/jbcpp-2021-0132","DOI":"10.1515\/jbcpp-2021-0132"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320916655"},{"issue":"1","key":"e_1_2_12_52_1","article-title":"Evaluation of serum Interleukin\u20106 and c\u2010reactive protein levels in drug\u2010na\u00efve major depressive disorder patients","volume":"11","author":"Nishuty NL","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312118773953"},{"issue":"11","key":"e_1_2_12_54_1","article-title":"Evaluation of serum glial cell line\u2010derived neurotrophic factor in Bangladeshi major depressive disorder patients","volume":"11","author":"Das R","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001084"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(94)00101-M"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.12.064"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1685-z"},{"issue":"10","key":"e_1_2_12_59_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276619","article-title":"Altered serum adiponectin and interleukin\u20108 levels are associated in the pathophysiology of major depressive disorder: a case\u2010control study","volume":"17","author":"Islam S","year":"2022","journal-title":"PLoS One"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.1005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:32:56Z","timestamp":1692862376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,24]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/hsr2.1005"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1005","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,24]]},"assertion":[{"value":"2022-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1005"}}