{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:16:21Z","timestamp":1780326981767,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>The study aimed to examine parental, longitudinal and current associative factors for atopic dermatitis (AD) and to compare those to other atopic diseases in 46\u2010year\u2010old adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Questionnaire data from the Northern Finland Birth Cohort 1966 study were used. To analyze allergic sensitization, skin prick tests (<jats:italic>n<\/jats:italic>\u2009=\u20095373) were performed for birch, timothy, cat, and house dust mite at age 46.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal (odds ratio [OR]\u00a01.81; 95% confidence interval [CI]\u00a01.25\u20132.59)\u00a0and paternal allergy (OR 2.54; CI 1.76\u20133.64), sensitization to any of the four tested aeroallergens (OR 1.56; CI 1.04\u20132.30) as well as polysensitization (OR 3.04; CI 2.10\u20134.37) were associated with current AD. Living on a farm in infancy was negatively associated with allergic rhinitis, allergic conjunctivitis, and atopic multimorbidity. Current AD (OR 2.65; CI 1.44\u20134.60) and all atopic diseases associated with indoor air related symptoms. Current AD associated with other atopic diseases, most strongly with allergic rhinitis (OR 4.92; CI 3.92\u20136.22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current AD in a 46\u2010year\u2010old general population occurred frequently with allergic rhinitis, allergic conjunctivitis, and asthma in the Northern Finland Birth Cohort study 1966. Parental allergy and sensitization to common aeroallergens were found as shared associative factors for AD, allergic rhinitis, allergic conjunctivitis, and asthma. AD and other atopic diseases associated with symptoms related to poor indoor air quality. In daily practice, it is important to take these comorbidities into consideration when treating patients with AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1015","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T08:15:45Z","timestamp":1671869745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associative factors for atopic dermatitis and other atopic diseases in middle\u2010aged adults: A population\u2010based birth cohort study among 5373 subjects"],"prefix":"10.1002","volume":"6","author":[{"given":"Anna K.","family":"Haarala","sequence":"first","affiliation":[{"name":"The Department of Dermatology, University Hospital of Oulu PEDEGO Research Unit  Oulu Finland"},{"name":"Medical Research Center, PEDEGO Research Group University of Oulu  Oulu 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