{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:49:44Z","timestamp":1762868984439,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Coronavirus is an infectious disease that is now known as an epidemic, early and accurate diagnosis helps the patient receive more care. The aim of this study is to investigate Covid\u201019 using blood tests and multilayer perceptron neural network and affective factors in improving and preventing Covid\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was performed on 200 patients referred to Sina Hospital, Tehran, Iran, who were confirmed cases of Covid\u201019 by computerized tomography\u2010scan analysis between 2 March 2020 to 5 April 2020. After verification of lung involvement, blood sampling was done to separate the sera for C\u2010reactive protein (CRP), magnesium (Mg), lymphocyte percentage, and vitamin D analysis in healthy and unhealthy people. Blood samples from healthy and sick people were applied to the multilayer perceptron network for 70% of the data for training and 30% for testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>By examining the features, it was found that in patients with Covid\u201019, there was a significant relationship between increased CRP and decreased lymphocyte levels, and increased Mg\u00a0(<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). In these patients, the amount of CRP and Mg in women and the number of lymphocytes and vitamin D in men were significantly higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The important advantage of using a multilayer perceptron neural network is to speed up the diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1048","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T13:38:50Z","timestamp":1673012330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of effective features in the diagnosis of Covid\u201019 infection from routine blood tests with multilayer perceptron neural network: A cross\u2010sectional study"],"prefix":"10.1002","volume":"6","author":[{"given":"Fatemeh","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Pathology, Sina Clinical\u2010Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Dehbozorgi","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Central Tehran Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9132-071X","authenticated-orcid":false,"given":"Hamid Reza","family":"Akbari\u2010Hasanjani","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, School of Chemistry Damghan University  Damghan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Joz Abbasalian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sina Clinical\u2010Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Akbari\u2010Hasanjani","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Central Tehran Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Sabbaghi\u2010Nadooshan","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Central Tehran Branch Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedieh","family":"Moradi Tabriz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sina Clinical\u2010Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-020-01597-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00477-020-01827-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26097"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"187","article-title":"Vitamin D and Coronavirus Disease (COVID\u201019); is deficiency and maintenance supplementation therapy necessary?","volume":"5","author":"Namayandeh SM","year":"2020","journal-title":"J Nutr Food Secur"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010236"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.06.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11403"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa270"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.030924"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173546"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.04.050"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nfs.2020.06.001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.111055"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.3001973"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","unstructured":"AbroudiA FarokhiF. 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