{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:32:37Z","timestamp":1787848357428,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although many angiotensin receptor blockers (ARBs) are widely used, comparative data regarding their impact on clinical outcomes are limited. We aimed to compare the clinical effectiveness of seven ARBs on long\u2010term cardiovascular outcomes in Korean patients with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Korean National Health Insurance Service database, the data of 780,785 patients with hypertension without cardiovascular disease (CVD) who initiated ARB treatment (candesartan, fimasartan, irbesartan, losartan, olmesartan, telmisartan, or valsartan) in 2014 and underwent this treatment for more than 6 months, were analyzed. Cox\u2010regression analysis was performed using Losartan as a comparator, as it was the most widely used drug, by adjusting age, sex, diabetes, dyslipidemia, smoking, alcohol drinking, exercise, body mass index, systolic blood pressure, albuminuria, estimated glomerular filtration rate, and concomitant medications. The occurrence of mortality and the rate of major adverse cardiovascular events (MACEs) of the six ARBs was compared with that of losartan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up duration was 5.94 (interquartile range, 5.87\u20135.97) years. In the crude analysis of all\u2010cause mortality and MACEs, fimasartan exhibited the lowest event rates. In the Cox\u2010regression analysis with adjustment, there was no significant difference in all\u2010cause mortality among ARBs. The risk of MACEs with ARBs was similar to that with losartan, although the risks with irbesartan (hazard ratio [HR], 1.079; 95% confidence interval [CI], 1.033\u20131.127;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and candesartan (HR: 1.066; 95% CI,\u00a01.028\u20131.106;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) were slightly higher.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a Korean population of patients with hypertension without CVD, six different ARBs showed similar efficacy to losartan in terms of long\u2010term mortality and MACEs. Further well\u2010designed prospective studies are required to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1056","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:25:03Z","timestamp":1675211103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term mortality and cardiovascular events of seven angiotensin receptor blockers in hypertensive patients: Analysis of a national real\u2010world database: A retrospective cohort study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-841X","authenticated-orcid":false,"given":"Wonjae","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology,\u00a0Department of Internal Medicine, Cardiovascular Center Seoul National University Bundang Hospital Seongnam\u2010si Gyeonggi\u2010do South 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