{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:41:54Z","timestamp":1782492114309,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Patients with pediatric\u2010onset primary sclerosing cholangitis (PSC) are at risk of developing hepatic complications with liver transplantation as only curative treatment. Complications usually occur over many years, underlining the need for reliable surrogate markers to predict the clinical course. Recently, gamma\u2010glutamyl transferase (GGT) has been suggested to allow prediction of the clinical course. In a single\u2010center cohort study, we tested the potency of GGT in this respect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used longitudinal data of patients from our academic center, diagnosed with pediatric\u2010onset PSC between 2000 and 2020. Patients with a GGT decrease from baseline &gt;25% (<jats:italic>n<\/jats:italic>\u2009=\u200936) were compared with those who did not have this decrease (<jats:italic>n<\/jats:italic>\u2009=\u20097). We performed Kaplan\u2013Meier analysis and log\u2010rank testing to assess the occurrence of portal hypertensive or biliary complications, hepatobiliary malignancies, liver transplantation, or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age diagnosis was 15.2 years and 12.1 years in the group with \u226425% decrease of GGT and the group with &gt;25% decrease, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.078). The probability of developing \u22651 complications in the first 5 years after diagnosis was 50% in the group with \u226425% decrease of GGT and 20% in the group with &gt;25% decrease of GGT (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). The use of medication was not associated with the development of complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a retrospective cohort study, we report that a GGT decrease of &gt;25% within 1 year of diagnosis of pediatric\u2010onset PSC is associated with a lower occurrence of complications within 5 years. Our results provide further support for the recently hypothesized predictive value of first\u2010year GGT change in predicting the disease course in pediatric\u2010onset PSC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1086","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T04:03:33Z","timestamp":1675310613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gamma\u2010glutamyl transferase and disease course in pediatric\u2010onset primary sclerosing cholangitis: A single\u2010center cohort study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-3148","authenticated-orcid":false,"given":"Besrat","family":"Berhane","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology &amp; Hepatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-2665","authenticated-orcid":false,"given":"Patrick F.","family":"van Rheenen","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology &amp; Hepatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-2861","authenticated-orcid":false,"given":"Henkjan J.","family":"Verkade","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology &amp; Hepatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60096-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13110"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1251"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0620-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14159"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31393"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.331"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.02.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1506330"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.032"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1258\/0004563021901685"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.01.039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29204"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.1086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:49:59Z","timestamp":1692319799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/hsr2.1086"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1086","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1086"}}