{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:27:40Z","timestamp":1771680460418,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","award":["PHRC\u2010N 2012\u2010A00347\u201036"],"award-info":[{"award-number":["PHRC\u2010N 2012\u2010A00347\u201036"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Little is known about the consequences of chronic sarcoidosis on daily life physical activity (DL<jats:sub>PA<\/jats:sub>). The aim of this prospective study was to measure DL<jats:sub>PA<\/jats:sub> in patients with chronic sarcoidosis and to determine its relationship to clinical and functional parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients with chronic sarcoidosis and 28 healthy control subjects were enrolled in this multicenter prospective study. Two markers of DL<jats:sub>PA<\/jats:sub> (number of steps walked per day [SPD]) and total daily energy expenditure (TEE) were assessed for five consecutive days with a physical activity monitor. Pulmonary function, aerobic capacity (maximal oxygen uptake [VO<jats:sub>2<\/jats:sub>max]), exercise capacity (6\u2010min walk test [6MWT]), and quality of life (self\u2010reported questionnaires) were also evaluated. Comparisons of DL<jats:sub>PA<\/jats:sub> parameters between the two groups were performed using an analysis of covariance adjusted for age, sex, and body mass index (BMI). Relationships between DL<jats:sub>PA<\/jats:sub> parameters and patient characteristics were assessed in multivariable linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with sarcoidosis walked significantly fewer SPD than did the control subjects (6395\u00a0\u00b1\u00a04119 and 11\u00a0817\u00a0\u00b1\u00a03600, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 after adjustment for age, BMI, and sex). TEE was not significantly different between patients with sarcoidosis and healthy controls (median [interquartile range]: 2369 [2004\u20102827] and 2387 [2319\u20102876] kcal\/day, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.054 adjusted for age, BMI, and sex). SPD showed significant positive correlations with 6MWT distance (Pearson's correlation, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.32, 95% confidence intervals [95%CI]\u00a0=\u00a00.06, 0.55; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019), VO<jats:sub>2<\/jats:sub>max (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44, 95%CI\u00a0=\u00a00.17, 0.65; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), and Visual Simplified Respiratory Questionnaire score (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44, 95%CI\u00a0=\u00a00.19, 0.64; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and a significant negative correlation with modified Medical Research Council questionnaire score (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.38, 95%CI\u00a0=\u00a0\u22120.60, \u22120.10; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). TEE was significantly correlated with BMI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.38, 95%CI\u00a0=\u00a00.13, 0.59; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), forced expiratory volume in 1\u00a0second (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.55, 95%CI\u00a0=\u00a00.33, 0.71; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), total lung capacity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44, 95%CI\u00a0=\u00a00.18, 0.64; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and forced vital capacity (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.56, 95%CI\u00a0=\u00a00.34, 0.72; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In multivariable analysis, SPD remained associated only with VO<jats:sub>2<\/jats:sub>max.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with chronic sarcoidosis appear to have reduced DL<jats:sub>PA<\/jats:sub> mainly because of compromised VO<jats:sub>2<\/jats:sub>max.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.109","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T12:59:38Z","timestamp":1547557178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study"],"prefix":"10.1002","volume":"2","author":[{"given":"Sarah","family":"Froidure","sequence":"first","affiliation":[{"name":"Service de Pneumologie et ImmunoAllergologie, Centre de comp\u00e9tence des maladies rares and Univ. Lille CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeva","family":"Kyheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marie","family":"Grosbois","sequence":"additional","affiliation":[{"name":"FormAction Sant\u00e9, Home\u2010based pulmonary rehabilitation team, rue Pietralunga  P\u00e9renchies France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Lhuissier","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Laboratoire Hypoxie et Poumon Universit\u00e9 Paris 13  Bobigny France"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris, H\u00f4pital Avicenne Service de Physiologie, explorations fonctionnelles et m\u00e9decine du sport  Bobigny France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Stelianides","sequence":"additional","affiliation":[{"name":"Division of Pneumology, Bichat Hospital, APHP Paris\u2010Diderot University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidwine","family":"Wemeau","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et ImmunoAllergologie, Centre de comp\u00e9tence des maladies rares and Univ. 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