{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:54:34Z","timestamp":1776999274690,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Central nervous system (CNS) infection is one of the most common causes of morbidity, mortality, and hospital admission worldwide. The natural history of CNS infection is quite fatal. Early diagnosis and treatment have been proven to have a crucial role in patients' survival. The aim of this study was to identify the epidemiological and clinical patterns of patients diagnosed with CNS infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a retrospective study conducted in a tertiary level hospital in Nepal in which patient diagnosed with CNS infections (September 2019 to 2021) were included. Data were collected and analyzed in SPSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the 95 patients included in the study was 45.18\u2009\u00b1\u200919.56. Meningoencephalitis (<jats:italic>n<\/jats:italic>\u2009=\u200944, 46.30%) was the most common infection diagnosed. Patients belonging to the age group 30\u221260 years had a higher frequency of focal neurological deficit, and other classical clinical features. All the patients who died during the treatment had associated comorbidities but no concurrent infections. Altered sensorium, fever, and headache were the common presenting symptoms in all the recovered patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To ensure optimum disease outcome, early diagnosis\u00a0and prompt management are crucial. For this, recognizing the local disease patterns in terms of disease distribution, commonly implicated aetiologies, presenting symptoms, and prognostic factors is of utmost importance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1099","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T12:42:15Z","timestamp":1675687335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological and clinical characteristics of central nervous system infections in a tertiary center: A retrospective study"],"prefix":"10.1002","volume":"6","author":[{"given":"Bikram P.","family":"Gajurel","sequence":"first","affiliation":[{"name":"Department of Neurology Tribhuvan University Teaching Hospital  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-5232","authenticated-orcid":false,"given":"Subarna","family":"Giri","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Rayamajhi","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niharika","family":"Khanal","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Bishowkarma","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine  Kathmandu 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