{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:31:36Z","timestamp":1790965896358,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Filarial infections affect over 150 million people in the tropics. One of the major forms of filarial pathologies is lymphedema; a condition where the immune response is significantly altered, resulting in changes in the normal flora. <jats:italic>Staphylococcus hominis<\/jats:italic>, a human skin commensal, can also be pathogenic in immunocompromised individuals. Therefore, there is the possibility that <jats:italic>S. hominis<\/jats:italic> could assume a different behavior in filarial lymphedema patients. To this end, we investigated the levels of antibiotic resistance and extent of <jats:italic>mec<\/jats:italic>A gene carriage in <jats:italic>S. hominis<\/jats:italic> among individuals presenting with filarial lymphedema in rural Ghana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We recruited 160 individuals with stages I\u2013VII lymphedema, in a cross\u2010sectional study in the Ahanta West District of the Western Region of Ghana. Swabs from lymphedematous limb ulcers, pus, and cutaneous surfaces were cultured using standard culture\u2010based techniques. The culture isolates were subjected to Matrix\u2010Assisted Laser Desorption\/Ionization Time of Flight (MALDI\u2010TOF) mass spectrometry for bacterial identification. Antimicrobial susceptibility testing (AST) was performed using the Kirby\u2013Bauer method. <jats:italic>mec<\/jats:italic>A genes were targeted by polymerase chain reaction for strains that were cefoxitin resistant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 112 <jats:italic>S<\/jats:italic>. <jats:italic>hominis<\/jats:italic> were isolated. The AST results showed resistance to chloramphenicol (87.5%), tetracycline (83.3%), penicillin (79.2%), and trimethoprim\/sulphamethoxazole (45.8%). Of the 112 strains of <jats:italic>S. hominis<\/jats:italic>, 51 (45.5%) were resistant to cefoxitin, and 37 (72.5%) of the cefoxitin\u2010resistant <jats:italic>S. hominis<\/jats:italic> haboured the <jats:italic>mec<\/jats:italic>A gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates a heightened level of methicillin\u2010resistant <jats:italic>S. hominis<\/jats:italic> isolated among filarial lymphedema patients. As a result, opportunistic infections of <jats:italic>S. hominis<\/jats:italic> among the already burdened filarial lymphedema patients in rural Ghana may have reduced treatment success with antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1104","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T13:52:30Z","timestamp":1675777950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antibiotic resistance and <i>mec<\/i>A characterization of <i>Staphylococcus hominis<\/i> from filarial lymphedema patients in the Ahanta West District, Ghana: A cross\u2010sectional study"],"prefix":"10.1002","volume":"6","author":[{"given":"Priscilla","family":"Kini","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-6114","authenticated-orcid":false,"given":"Solomon","family":"Wireko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana"},{"name":"Department of Laboratory Technology Kumasi Technical University Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-2503","authenticated-orcid":false,"given":"Priscilla","family":"Osei\u2010Poku","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-3195","authenticated-orcid":false,"given":"Samuel O.","family":"Asiedu","sequence":"additional","affiliation":[{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana"},{"name":"Department of Theoretical and Applied Biology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel K. 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