{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:28Z","timestamp":1786977808042,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In Myanmar, public sector treatment programs for hepatitis C virus (HCV) infection were nonexistent until June 2017. WHO highlights the importance of simplification of HCV service delivery through task\u2010shifting among health workers and decentralization to the primary health care level. Between November 2016 and November 2017, a study was conducted to describe the epidemiological data and real\u2010world outcomes of treating HIV\/HCV coinfected patients with generic direct acting antiviral (DAA) based regimens in the three HIV clinics run by nonspecialist medical doctors in Myanmar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HCV co\u2010infection among people living with HIV (PLHIV) from two clinics in Yangon city and one clinic in Dawei city was screened by rapid diagnostic tests and confirmed by testing for viral RNA. Nonspecialist medical doctors prescribed sofosbuvir and daclatasvir based regimens (with or without ribavirin) for 12 or 24 weeks based on the HCV genotype and liver fibrosis status. Sustained virologic response at 12 weeks after treatment (SVR12) was assessed to determine cure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>About 6.5% (1417\/21,777) of PLHIV were co\u2010infected with HCV. Of 864 patients enrolled in the study, 50.8% reported history of substance use, 27% history of invasive medical procedures and 25.6% history of incarceration. Data on treatment outcomes were collected from 267 patients of which 257 (96.3%) achieved SVR12, 7 (2.6%) failed treatment, 2 (0.7%) died and 1 (0.4%) became loss to follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study results support the integration of hepatitis C diagnosis and treatment with DAA\u2010based regimens into existing HIV clinics run by nonspecialist medical doctors in a resource\u2010limited setting. Epidemiological data on HIV\/HCV co\u2010infection call for comprehensive HCV care services among key populations like drug users and prisoners in Yangon and Dawei.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1119","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T13:05:45Z","timestamp":1676725545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological characteristics and real\u2010world treatment outcomes of hepatitis C among HIV\/HCV co\u2010infected patients in Myanmar: A prospective cohort study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-4016","authenticated-orcid":false,"given":"Thein Min","family":"Swe","sequence":"first","affiliation":[{"name":"Medecins Sans Frontieres Dawei Myanmar"},{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek. C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Htay Thet","family":"Mar","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phone","family":"Thit","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Homan","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherry May","family":"Chu","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Dawei Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyu Ei","family":"Mon","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Dawei Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thin Thin","family":"Thwe","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyi Pyar","family":"Soe","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Dawei Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win Le Shwe Sin","family":"Ei","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyan Lynn","family":"Tun","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyaw Zay","family":"Lwin","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayk","family":"Karakozian","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khin Sanda","family":"Aung","sequence":"additional","affiliation":[{"name":"National Hepatitis Control Program, Ministry of Health and Sports Naypyitaw Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Geneva Switzerland"},{"name":"Infectious Diseases Unit, Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iza","family":"Ciglenecki","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Medecins Sans Frontieres Dawei Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Loarec","sequence":"additional","affiliation":[{"name":"Epicentre, Medecins Sans Frontieres Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization. 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WHO Myanmar newsletter special for World Hepatitis Day 28 July 2020.\u00a0Accessed August 24 2022.\u00a0https:\/\/cdn.who.int\/media\/docs\/default-source\/searo\/myanmar\/factsheet-viral-hepatitis-2020-v2.pdf?sfvrsn=8f334662_0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"e_1_2_11_16_1","unstructured":"US Department of Veterans Affairs. Hepatitis C RNA quantitative testing: test of hepatitis C\u2014viral hepatitis and liver disease.\u00a0Accessed August 29 2022.\u00a0https:\/\/www.hepatitis.va.gov\/hcv\/patient\/diagnosis\/labtests-RNA-quantitative-testing.asp"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01180.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197544"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-9891-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz100"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14983"},{"key":"e_1_2_11_22_1","unstructured":"BwaAH MaungST HtarSS et al. Oral Direct Acting Antivirals (DAAs) Therapy of patients (n\u2009=\u2009261) with Chronic HCV genotype 3 infection\u2014real life Myanmar experience. 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