{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:46:35Z","timestamp":1778165195313,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006070","name":"Universidad de los Andes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Acute respiratory failure (ARF) is a common cause of morbimortality, and a frequent reason for admission to the pediatric intensive care unit (PICU).\u00a0It requires a high\u2010flow oxygen device as treatment. Our aim is to determine the frequency and main indications for the use of high\u2010flow nasal cannula (HFNC), and the prevalence of HFNC failure and its main causes, in three hospitals<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It is a multicenter prospective cohort study, developed in three hospitals in Bogota. Eligible patients were children older than 1\u00a0month and younger than 18 years who presented ARF and required management with an HFNC. The study was carried out between April 2020 and December 2021. The follow\u2010up was carried out at 1, 6, and 48\u2009h after starting the management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 685 patients included in the study, 296 developed ARF. The prevalence of patients with ARF who required management with HFNC was 48%. The frequency of the pathologies that cause the ARF was: Bronchiolitis was the most frequent pathology (34.5%), followed by asthmatic crisis (15.5%)\u00a0and pneumonia (12.7%). The average time of use of HFNC was 81.6\u2009h. Regarding treatment failure with HFNC, 15 patients presented torpid evolution and required invasive mechanical ventilation, with a prevalence of therapeutic failure of the HFNC of 10.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of HFNC is more frequent in patients with bronchiolitis, in children under 2 years of age and in males, which is in line with what has been reported in the literature. In addition, the failure rate of HFNC is low (10.6%), and it may be useful in other pathologies besides bronchiolitis, such as asthma, pneumonia, among others. It opens the possibility to continue evaluating the role of HFNC in pediatric pathology in new studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1182","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T04:29:00Z","timestamp":1680409740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of high\u2010flow cannula in pediatric patients with respiratory failure: A prospective cohort study in three high\u2010altitude hospitals"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-4062","authenticated-orcid":false,"given":"Natalia","family":"Ante\u2010Ardila","sequence":"first","affiliation":[{"name":"Department of Pediatrics Universidad de los Andes Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9278-947X","authenticated-orcid":false,"given":"Camilo 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