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Keeping mf under a certain threshold within endemic populations will stop transmission and eliminate the infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A narrative review was carried out to identify the possibilities and limitations of exploring the use of eosinophil responses as an anti\u2010filarial vaccine, and biomarker for the detection of filarial infections. An extensive literature search was performed in online scientific databases including PubMed Central, PubMed, BioMed Central, with the use of predefined search terms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A better understanding of the parasite\u2010host interactions will lead to the development of improved and better treatment or vaccine strategies that could eliminate filariasis as soon as possible. Highlighted in this review is the explorative use of eosinophil\u2010producing CLC\/Galectin\u201010 as a potential biomarker for filarial infections. Also discussed are some genes, and pathways involved in eosinophil recruitments that could be explored for anti\u2010filarial vaccine development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this short communication, we discuss how eosinophil\u2010regulated genes, pathways, and networks could be critical in providing more information on how reliably a front\u2010line immune player could be exploited for anti\u2010filarial vaccine development and early infection biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1320","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:34:13Z","timestamp":1686173653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophil: An innate immune cell with anti\u2010filarial vaccine and biomarker 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