{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:34Z","timestamp":1790806414997,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study was performed on 219 women aged 25\u201335 years who were referred to the gynecologic oncology clinic during 2019\u20132020. The positive or negative HPV infection was confirmed by cervical biopsy and polymerase chain reaction (PCR) test. Cervical lesions or abnormalities in the cervix were assessed by colposcopy and histopathological analysis. Serum anti\u2010Mullerian hormone (AMH) levels were measured for all participants to assess ovarian reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study showed that in patients who were HPV positive, decreased ovarian reserve was more common than in the HPV negative group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). Also, there was a significant difference between Cervical intraepithelial neoplasia (CIN) I and CIN III sub\u2010groups in AMH level (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Traces of HPV have been observed in various aspects of infertility, but no study has been performed on its association with ovarian reserve. According to the results of this study, decreased ovarian reserve was more common in patients who were HPV positive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1343","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T12:03:05Z","timestamp":1689854585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk of decreased ovarian reserve in women with HPV infection and cervical lesions"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3308-1076","authenticated-orcid":false,"given":"Fereshteh","family":"Fakor","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Reproductive Health Research Center, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-3955","authenticated-orcid":false,"given":"Nasrin G.","family":"Gashti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Reproductive Health Research Center, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-5390","authenticated-orcid":false,"given":"Amirhossein H.","family":"Fallah","sequence":"additional","affiliation":[{"name":"Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-6846","authenticated-orcid":false,"given":"Roya","family":"Kabodmehri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Reproductive Health Research Center, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-6983","authenticated-orcid":false,"given":"Zahra","family":"Rafiei Sorouri","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Reproductive Health Research Center, School of Medicine, Al\u2010zahra Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Hasanzadi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Reproductive Health Research Center, School of Medicine, Al\u2010zahra Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-8771","authenticated-orcid":false,"given":"Zahra","family":"Pourhabibi","sequence":"additional","affiliation":[{"name":"Vice\u2010Chancellorship of Research 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