{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:51:20Z","timestamp":1790351480217,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that harbors the Philadelphia chromosome. Tyrosine kinase inhibitor (TKI) therapy has dramatically improved the survival of patients with CML. Nevertheless, 20%\u201340% of CML patients require changes in TKI therapy due to intolerance or drug resistance. A total of 30%\u201360% of resistant cases result from kinase domain (KD) mutations. There is currently no published data on CML KD mutations in South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, descriptive study collected data from 206 CML patients attending the King Edward Hospital Hematology clinic. Patient\u2010based and mutation\u2010based factors were analyzed using descriptive statistical analysis and Kaplan\u2013Meier curves for survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>KD mutations were detected in 29.1% (<jats:italic>n<\/jats:italic>\u2009=\u200960 of 206). A total of 40 different KD mutations were detected, with unknown responses to TKI therapy in 65% (<jats:italic>n<\/jats:italic>\u2009=\u200926 of 40). A total of 57.7% (<jats:italic>n<\/jats:italic>\u2009=\u200915 of 26) of mutations with an unknown response, showed a response to specific TKIs in our study. Four patients had A399T mutations, of which two showed good responses to Nilotinib. Patients with I293N and V280M mutations showed good responses to Imatinib. G250E was most frequently detected. Despite M351T being one of six most commonly reported KD mutations globally, this mutation was not detected in our patient cohort. A total of 20.9% (<jats:italic>n<\/jats:italic>\u2009=\u200943 of 206) human immunodeficiency virus (HIV) positive patients were identified, of which 25.6% (<jats:italic>n<\/jats:italic>\u2009=\u200911 of 43) had KD mutations. HIV status showed no significant effect on mutational status or overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The predicted response to TKI therapy was unknown in more than half of the KD mutations detected in our patient population. Additionally, eight patients with mutations with known responses to TKIs showed responses discordant to that expected. HIV status and KD mutations had no statistically significant effect on overall survival. Although some data were comparable to international publications, few notable differences warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1376","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T04:50:37Z","timestamp":1688187037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chronic myeloid leukemia kinase domain mutations: A retrospective descriptive study on the therapeutic and prognostic significance in patients at King Edward VIII Hospital, KwaZulu\u2010Natal, South Africa"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-7631","authenticated-orcid":false,"given":"Caryn","family":"Benjamin","sequence":"first","affiliation":[{"name":"National Health Laboratory Service  Durban KwaZulu Natal South Africa"},{"name":"University of KwaZulu Natal  Durban KwaZulu Natal South 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