{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:12:54Z","timestamp":1789096374426,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102, as a new pandemic disease, affected the world. Short\u2010chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids are the main metabolites of human gut microbiota. The positive effects of SCFAs have been shown in infections caused by respiratory syncytial virus, adenovirus, influenza, and rhinovirus. Therefore, this study aimed to evaluate the concentration of SCFAs in patients with SARS\u2010CoV\u20102 compared with the healthy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This research was designed based on a case and control study. Twenty healthy individuals as the control group and 20 persons admitted to the hospital with a positive test of coronavirus disease (COVID\u201019) real\u2010time polymerase chain reaction were included in the study as the patient group from September 2021 to October 2021, in Tabriz, Iran. Stool specimens were collected from volunteers, and analysis of SCFAs was carried out by a high\u2010performance liquid chromatography system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The amount of acetic acid in the healthy group was 67.88\u2009\u00b1\u200923.09\u2009\u03bcmol\/g, while in the group of patients with COVID\u201019 was 37.04\u2009\u00b1\u200913.29\u2009\u03bcmol\/g. Therefore, the concentration of acetic acid in the patient group was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) lower than in the healthy group. Propionic and butyric acid were present in a higher amount in the control group compared with the case group; however, this value was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that the concentration of acetic acid as the metabolite caused by gut microbiota is significantly disturbed in patients with COVID\u201019. Therefore, therapeutic interventions based on gut microbiota metabolites in future research may be effective against COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1411","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T04:55:44Z","timestamp":1688619344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short\u2010chain fatty acids profile in patients with SARS\u2010CoV\u20102: A case\u2010control study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-8382","authenticated-orcid":false,"given":"Edris","family":"Nabizadeh","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-4753","authenticated-orcid":false,"given":"Mohammad Yousef","family":"Memar","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Hamishehkar","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ghanbari","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiva","family":"Kadkhoda","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-309X","authenticated-orcid":false,"given":"Solmaz","family":"Asnaashari","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Samadi","family":"Kafil","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Varshochi","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Mostafazadeh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Clinical Laboratories Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Hosseinpour","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-3558","authenticated-orcid":false,"given":"Reza","family":"Ghotaslou","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.065"},{"key":"e_1_2_12_6_1","article-title":"Virological assessment of SARS\u2010CoV\u20102","volume":"26","author":"Stower H","year":"2020","journal-title":"Nature Med"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0817-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1242-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.10.1221"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00217-18"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr358"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37944"},{"key":"e_1_2_12_14_1","first-page":"2978","article-title":"Impact of gut colonization with butyrate\u2010producing microbiota on respiratory viral infection following allo\u2010HCT","volume":"131","author":"Haak BW","year":"2018","journal-title":"Blood J Am Soc Hematol"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.02.032"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/08850666221102796"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14562"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103891"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091977"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.007"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.082"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13119"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016509"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211027798"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114414"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1874740"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T01:45:25Z","timestamp":1706147125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/hsr2.1411"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1411","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1411"}}