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There are three isoforms of fibrillin molecules identified in mammals: fibrillin 1 (FBN1), fibrillin 2 (FBN2), and fibrillin 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Multiple studies have shown that mutations in these genes or changes in their expression levels can be related to various diseases, including cancers. In this study, we focus on reviewing the role of the fibrillin family in multiple cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We performed a comprehensive literature review to search PubMed and Google Scholar for studies published so far on fibrillin gene expression and its role in cancers. In this review, we have focused on the expression of <jats:italic>FBN1<\/jats:italic> and <jats:italic>FBN2<\/jats:italic> genes in cancers such as the lung, intestine, ovary, pancreatic ductal, esophagus, and thyroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altogether various studies showed higher expression of fibrillins in different tumor tissues correlated with the patient's survival. However, there are controversial findings, as some other cancers showed hypermethylated <jats:italic>FBN<\/jats:italic> promoters with lower gene expression levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1434","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T13:56:11Z","timestamp":1689688571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of fibrilins in human cancer: A narrative review"],"prefix":"10.1002","volume":"6","author":[{"given":"Mahsa","family":"Mahdizadehi","sequence":"first","affiliation":[{"name":"Metabolic Disorders Research Center Golestan University of Medical Sciences Gorgan Iran"},{"name":"Department of Biochemistry and Biophysics, Faculty of Medicine Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Saghaeian 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