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Liver biopsy has historically been the gold standard for identifying advanced hepatic fibrosis, but this approach has several limitations, including invasiveness, low applicability, sampling variability, and cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Text<\/jats:title><jats:p>In order to detect earlier features of advanced liver fibrosis, surrogate biomarkers and techniques have been developed. While these were initially developed for chronic liver diseases such as viral hepatitis and nonalcoholic fatty liver disease (NAFLD), their performance in ALD has also been recently studied. Among the noninvasive surrogate markers and techniques used to detect liver fibrosis, the Enhanced Liver Fibrosis test, FibroTest, and Transient Elastography are the most accurate and validated techniques. In this review, we summarize the current status of the noninvasive assessment of liver disease in ALD and provide a synthesis of how these noninvasive tools can be used in clinical practice. Finally, we briefly outline novel biomarkers that are currently being investigated and discuss future directions and new opportunities in the noninvasive diagnosis of ALD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.146","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T22:01:32Z","timestamp":1583704892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Noninvasive diagnosis in alcohol\u2010related liver disease"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6595-2809","authenticated-orcid":false,"given":"Alia","family":"Hadefi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology CUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Laboratory of Experimental Gastroenterology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Degr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology CUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Laboratory of Experimental Gastroenterology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tr\u00e9po","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology CUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Laboratory of Experimental Gastroenterology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology CUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Laboratory of Experimental Gastroenterology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_2_10_4_1","article-title":"Implementation of the Lancet Standing Commission on Liver Disease in the UK","volume":"21","author":"Williams R","year":"2015","journal-title":"Lancet (London, England)"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32866-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.007"},{"key":"e_1_2_10_8_1","volume-title":"Tackling Harmful Alcohol use: Economics and Public Health Policy","author":"Organisation for Economic Co\u2010Operation and Development","year":"2015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.011"},{"key":"e_1_2_10_10_1","unstructured":"European Association for the Study of the Liver.EASL HEPAHEALTH project report 2018: risk factors and the burden of liver disease in Europe and selected Central Asian countries.2018. 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