{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:52Z","timestamp":1759335652710,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["H17\/01\/a0\/004","H19\/01\/a0\/0Y9"],"award-info":[{"award-number":["H17\/01\/a0\/004","H19\/01\/a0\/0Y9"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Venous leg ulcers (VLUs) are associated with significant morbidity and poor quality of life (QOL). Compression therapy and wound dressing are the mainstay treatment options. Technology Lipido\u2010Colloid Impregnated with Silver (TLC\u2010Ag) reduces bacterial load and Technology Lipido\u2010Colloid Nano\u2010Oligosaccharide Factor (TLC\u2010NOSF) reduces elevated matrix metalloproteinases and improve wound healing. However, evidence is scarce on the role of sequential therapy. This study aims to evaluate if sequential treatment with TLC\u2010Ag and TLC\u2010NOSF improves VLU wound healing and QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective cohort study from May 2020 to October 2021 on patients with VLUs who received sequential therapy, consisting of 2 weeks of TLC\u2010Ag followed by two\u2010layer compression bandage (2LB) with TLC\u2010NOSF until complete wound healing. Participants were followed\u2010up with weekly dressing changes. Our primary outcomes were wound area reduction (WAR) and Pressure Ulcer Scale of Healing (PUSH) score. Our secondary outcomes were QOL measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 28 patients with 57.1% males (<jats:italic>n<\/jats:italic>\u2009=\u200916) with a mean age of 65.3 years. Mean duration of VLU was 13.9\u2009\u00b1\u200911.7 weeks before the initiation of sequential therapy. Mean baseline wound area was 8.44\u2009cm<jats:sup>2<\/jats:sup>. Median time to wound healing was 10 weeks. 57.1% of patients achieved complete wound closure at 3 months. There was significant WAR after 1 month (mean area 8.44\u20135.81 cm<jats:sup>2<\/jats:sup>, 31.2% decrease) and after 3 months (mean area 8.44\u20132.53 cm<jats:sup>2<\/jats:sup>, 70.0% decrease). Mean monthly WAR was 28.9%. PUSH score also decreased at 1 month (16.5% decrease, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 3 months (63.3% decrease, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) marks following the sequential therapy. EuroQol Visual Analog Scale (EQ\u2010VAS) improved following sequential therapy (baseline: 69.0\u2009\u00b1\u200915.0, week 13: 80.2\u2009\u00b1\u200913.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sequential therapy with TLC\u2010Ag followed by TLC\u2010NOSF and 2LB is feasible, with good wound healing and improvement in QOL of patients with VLUs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1488","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:04:15Z","timestamp":1692849855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective study on the efficacy of sequential treatment of technology Lipido\u2010Colloid Impregnated with Silver and Technology Lipido\u2010Colloid Nano\u2010Oligosaccharide Factor in the management of venous leg ulcers"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-264X","authenticated-orcid":false,"given":"Natalie Shi Qi","family":"Wong","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey Hui Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Wound and Stoma Care, Nursing Specialty Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-801X","authenticated-orcid":false,"given":"Kai Siang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Vascular Surgery Service, Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine C. C.","family":"Goh","sequence":"additional","affiliation":[{"name":"Wound and Stoma Care, Nursing Specialty Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiting","family":"Lai","sequence":"additional","affiliation":[{"name":"Wound and Stoma Care, Nursing Specialty Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivakami","family":"Muthuveerappa","sequence":"additional","affiliation":[{"name":"Wound and Stoma Care, Nursing Specialty Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Maliki Bin","family":"Mohamed Nasir","sequence":"additional","affiliation":[{"name":"Wound and Stoma Care, Nursing Specialty Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanying","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vascular Surgery Woodlands Health Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiantai","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of General Surgery Vascular Surgery Service, Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-0066","authenticated-orcid":false,"given":"Enming","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of General Surgery Vascular Surgery Service, Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-5266","authenticated-orcid":false,"given":"Zhiwen Joseph","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vascular Surgery Woodlands Health Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore"},{"name":"Skin Research Institute of Singapore Agency for Science Technology and Research Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055289"},{"key":"e_1_2_11_3_1","first-page":"69","article-title":"Prevalence and risk factors for chronic venous insufficiency","volume":"1","author":"Fowkes F","year":"2000","journal-title":"Acta Phlebol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/153857449603000102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2017.70109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2015.05.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0343-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13333"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_11_10_1","article-title":"Compression bandages or stockings versus no compression for treating venous leg ulcers","volume":"7","author":"Shi C","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13644"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62368-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup12.S6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.2.96"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00797.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup4.S42"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.Sup1.12536"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12102"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2011.10.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.12.M795"},{"issue":"5","key":"e_1_2_11_21_1","first-page":"58","article-title":"Use of the PUSH tool to measure venous ulcer healing","volume":"51","author":"Ratliff CR","year":"2005","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-11692007000300005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-018-0642-5"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-019-02128-6"},{"key":"e_1_2_11_25_1","unstructured":"Thejamovi project. Version 16. jamovi [Computer Software]; 2021."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000294757.05049.85"},{"key":"e_1_2_11_27_1","unstructured":"UrgoStart for treating diabetic foot ulcers and leg ulcers. Medical Technologies Guidance [MTG42]. NICE Guidance.2019."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup2.S4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14568677"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513476844"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5495"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1998.60206.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.3.164"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000693"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2009.14.Sup6.45538"},{"issue":"3","key":"e_1_2_11_36_1","article-title":"Health\u2010related quality of life and chronic venous leg ulceration: part 2","volume":"15","author":"Green J","year":"2010","journal-title":"Br J Community Nurs"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.11.553"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00524.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.185"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:22:36Z","timestamp":1700677356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/hsr2.1488"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1488","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"type":"print","value":"2398-8835"},{"type":"electronic","value":"2398-8835"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2022-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1488"}}