{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:23:28Z","timestamp":1780449808270,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["9811698007"],"award-info":[{"award-number":["9811698007"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Educational self\u2010management interventions (SMI) have an important role in improving symptom management, preventing relapse of multiple sclerosis (MS) and promoting quality of life (QoL) of these patients; since there is little knowledge about overall effectiveness of MS self\u2010management programs and which types of SMI improves the outcomes, this research aims to assess the efficacy of structured SMI in improving health outcomes in people with MS\u00a0(PwMS) by synthesizing and compare outcomes from related randomized controlled trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present systematic review protocol, the keywords related to self\u2010management and MS will be searched in electronic databases including (PubMed, Web of Science, Scopus, EMBASE, Cochrane Central Register of Controlled Trials\u00a0[CENTRAL]), gray literature resources and key journals from 2000 to July 2023. Research\u2010related articles will be collected and after removing duplicate articles, will be included in the study. In the screening step, titles and abstracts of articles will be reviewed and after deleting irrelevant articles, the full text of related articles will be evaluated independently by two researchers and data will be extracted from final articles and the findings will be categorized in an extraction table. Risk of bias will be assessed by using the Cochrane collaboration's tool. If possible, the data will be analyzed using random effect models and the statistical analysis will be performed using STATA software (version 14.2) developed by StataCorp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Comparative effectiveness of SMI is currently unknown. We will analyze outcome measures used to assess effectiveness of self\u2010management education in improving QoL, depression, self\u2010efficacy, pain, and fatigue. These findings will help identify the most promising components of SMIs, guiding targeted interventions for specific subpopulations, and facilitating the design of better interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1536","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:19:21Z","timestamp":1693829961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Self\u2010management interventions\u00a0for people with multiple sclerosis: A systematic review and meta\u2010analysis protocol"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-1171","authenticated-orcid":false,"given":"Reza","family":"Heidari\u2010Soureshjani","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Nikbakht","family":"Nasrabadi","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Zakerimoghadam","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayeb","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Rasti","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1006"},{"key":"e_1_2_10_3_1","volume-title":"Multiple Sclerosis in Children: Current and Emerging Concepts. 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