{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:28Z","timestamp":1753869208895,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Intestinal parasites affect the tuberculosis disease outcome by shifting the cell\u2010mediated to humoral immune response and host immune system suppression. However, <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (MTB) infection favors the immune escape of parasites. Hence, exploring the rate of intestinal parasitic coinfection with pulmonary tuberculosis (PTB) and its predisposing factors to take better preventive, control, and management measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A facility\u2010based cross\u2010sectional study was conducted from September to December 2020 at five health institutions in Hawassa city. A total of 214 PTB patients were diagnosed using the GeneXpert assay and enrolled in this study. Demographic, clinical, and risk factors data were collected using a structured questionnaire. Stool samples were collected using a clean, labeled, and leak\u2010proof stool cup. Stool samples were examined using direct saline microscopy and the formal\u2010ether concentration technique. The data were entered and coded in SPSS software for analysis. Bivariate and multivariate logistic regression were employed to identify the associated risk factors. A <jats:italic>p<\/jats:italic>\u2010value less than \u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall rate of intestinal parasitic\u2010MTB coinfection was 36.9%. The most dominant intestinal parasite was <jats:italic>Gardia lamblia<\/jats:italic> (17.8%, 38), followed by <jats:italic>Entamoeba histolytica<\/jats:italic>\/<jats:italic>dispar<\/jats:italic> (9.3%, 20). Intestinal parasitosis coinfection of PTB was associated with being rural resident (adjusted odds ratio [AOR]\u2009=\u20092.42; 95% confidence interval [CI]: 1.23\u20134.8), not washing of fruits and vegetables before eating [AOR\u2009=\u20094.14; 95% CI: 1.92\u20139], being at the early stage of anti\u2010TB treatment [AOR\u2009=\u20093; 95% CI: 1.5\u20136.3] and presence of chronic diseases [AOR\u2009=\u20097; 95% CI: 3.4\u201314].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The burden of intestinal parasites\u2010MTB coinfection was high. Those who wash fruits and vegetables before eating should be encouraged, early treatment of PTB patients and avoiding the practice of open\u2010field defecation, especially in rural communities, is necessary. The dual effect of coinfection on disease severity and treatment success needs further cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1569","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T08:30:03Z","timestamp":1695198603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnitude and predisposing factors of intestinal parasitosis and tuberculosis coinfection at five health institutions in Southern Ethiopia: A cross\u2010sectional study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6286-7564","authenticated-orcid":false,"given":"Agumas","family":"Shibabaw","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Medicine and Health Sciences Wollo University  Dessie 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