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This systematic review of peer\u2010reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022\u2010mpox outbreak.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 45 peer\u2010reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non\u2010endemic regions. Men (70%\u201398% cases) were mostly infected with homosexual and bisexual behavior (30%\u201360%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections\u00a0among 30%\u201360% of cases were reported. Human\u2010to\u2010human transmission via direct contact and different body fluids were involved in the majority of the cases (90%\u2013100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%\u201340%) and proctitis (20%\u201340%) were more common during 2022 outbreak than pre\u20102022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000\u00ae, are approved and used for pre\u2010 and post\u2010prophylaxis in cases. About 100% of the cases in non\u2010endemic regions were associated with isolates of IIb clade with a divergence of 0.0018\u20130.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1603","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:34:51Z","timestamp":1696613691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Molecular epidemiology, transmission and clinical features of 2022\u2010mpox outbreak: A systematic review"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-9726","authenticated-orcid":false,"given":"Nadim","family":"Sharif","sequence":"first","affiliation":[{"name":"Department of Microbiology Jahangirnagar University  Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmul","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Mathematics Rajshahi University of Engineering &amp; Technology  Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-0106","authenticated-orcid":false,"given":"Khalid J.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim F.","family":"Halawani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuad M.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences Taif University  Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel De la Torre","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"University of Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viv\u00edan","family":"Lipari","sequence":"additional","affiliation":[{"name":"Universidad Europea del Atl\u00e1ntico Santander Spain"},{"name":"Universidad Internacional Iberoamericana Arecibo Puerto Rico USA"},{"name":"Universidade Internacional do Cuanza Cuito Bi\u00e9 Angola"},{"name":"Fundaci\u00f3n Universitaria Internacional de Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel L\u00f3pez","family":"Flores","sequence":"additional","affiliation":[{"name":"Universidad Europea del Atl\u00e1ntico Santander Spain"},{"name":"Universidad Internacional Iberoamericana Campeche M\u00e9xico"},{"name":"Instituto Polit\u00e9cnico Nacional UPIICSA Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anowar K.","family":"Parvez","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University  Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-5673","authenticated-orcid":false,"given":"Shuvra K.","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jahangirnagar University  Savar Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Centers for Disease Control and Prevention. 2022Monkeypox Outbreak Global Map. 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