{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:32:51Z","timestamp":1793053971478,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>One of the most common hemoglobinopathies globally related to blood transfusion and iron overload in the body is thalassemia syndrome. Increasing ferritin levels can cause severe damage to the patient's body organs. This study aims to evaluate the complications of iron overload on vital body organs in patients with transfusion\u2010dependent beta\u2010thalassemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This descriptive cross\u2010sectional study was performed in Iran University of Medical Sciences Hospitals on patients with a beta\u2010thalassemia major with frequent blood transfusions. To evaluate the effect of iron overload on vital body organs, hematologic and blood analysis, echocardiography with measurement of pulmonary artery pressure (PAP) and ejection fraction (EF) tests, bone densitometry, and audiometric tests were performed for all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1010 patients participating in this study, 497 (49%) were males, 513 were (51%) females aged 5\u201374 years, and the majority of participants (85%) were over 20 years old. This study demonstrated that increasing ferritin levels had no notable correlation with sex, cholesterol, low\u2010density lipoprotein, parathyroid hormone, T4, and aspartate aminotransferase. However, elevating ferritin levels had significant correlations with increasing triglyceride, phosphorus, thyroid stimulating hormone, alkaline phosphatase, alanine transaminase, and PAP\u00a0levels, age, hearing disorders, splenectomy, osteoporosis, and decreasing high\u2010density lipoprotein, body mass index, calcium, and EF\u00a0levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Improvement in beta\u2010thalassemia patients' survival and quality of life can be due to multidisciplinary care in a comprehensive unit through regular follow\u2010up and early complication detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1624","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T02:37:04Z","timestamp":1697078224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Complications in patients with transfusion dependent thalassemia: A descriptive cross\u2010sectional study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-2347","authenticated-orcid":false,"given":"Mohammad","family":"Faranoush","sequence":"first","affiliation":[{"name":"Pediatric Growth and Development Research Center,\u00a0Institute of Endocrinology Iran University of Medical Sciences  Tehran Iran"},{"name":"Cardio\u2010Oncology Research Center, Rajaie Cardiovascular Medical &amp; Research Center Iran University of Medical Sciences  Tehran 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