{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:55:06Z","timestamp":1771023306528,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Hypothyroidism is the most common disease of the thyroid gland. Thyroid hormone plays a crucial role in regulating tissue growth and metabolism. Additionally, patients with thyroid dysfunction have a higher incidence of caries and periodontal problems. The presence of calcium and phosphate ions seems to be effective in remineralizing teeth and reducing caries. The aim of this study was to evaluate the salivary level of calcium in patients with hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study showed that saliva calcium concentration in patients with hypothyroidism is significantly lower than healthy subjects. Also, no significant association was found between salivary calcium levels and TSH and T4 hormones level of blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased prevalence of dental caries in patients with hypothyroidism may be related to a decrease in their calcium levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1669","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:41:45Z","timestamp":1698298905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating salivary concentration of calcium ion in hypothyroidism"],"prefix":"10.1002","volume":"6","author":[{"given":"Shiva","family":"Borzuei","sequence":"first","affiliation":[{"name":"Department of Community Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samaneh Vaziri","family":"Amjad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental School Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Badiei","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental School Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9671-1696","authenticated-orcid":false,"given":"Abbas","family":"Farmany","sequence":"additional","affiliation":[{"name":"Dental Implant Research Center Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Cheraghi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_574_18"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.247"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"139","article-title":"Oral health status of children suffering from thyroid disorders","volume":"34","author":"NS VB","year":"2020","journal-title":"J Indian Soc Pedodont Preventive Dentistr"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.17126\/joralres.2015.063"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01963-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784440"},{"issue":"4387","key":"e_1_2_12_8_1","first-page":"1","article-title":"Three\u2010dimensional observation and analysis of remineralization in dentinal caries lesions","volume":"10","author":"Kumiko Y","year":"2020","journal-title":"Sci Rep"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41405-020-0037-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaa003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2013.12222284"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0048-z"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"308","article-title":"A study of serum calcium, magnesium and phosphorous level in hypothyroidism patients","volume":"3","author":"Gohel MG","year":"2014","journal-title":"Int J Med"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2759040","article-title":"The effect of Ca and Mg concentrations and quantity and their correlation with caries intensity in school\u2010age children","volume":"2018","author":"Sejdini M","year":"2018","journal-title":"Int J Dent"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.118316"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.169846"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2016.38"},{"key":"e_1_2_12_18_1","volume-title":"Harrison's principles of internal medicine","author":"Kasper DL","year":"2018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0353"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126162"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9145-3"},{"key":"e_1_2_12_22_1","first-page":"13","article-title":"Evaluation of serum zinc, copper level and their correlation with Cu\/Zn ratio and FT3\/FT4 ratio in hypothyroidism","volume":"13","author":"Khatun S","year":"2019","journal-title":"J Clin Diagn Res"},{"issue":"10","key":"e_1_2_12_23_1","first-page":"6598","article-title":"Salivary calcium levels in hypothyroid patients: a case control study","volume":"6","author":"Anuradha A","year":"2015","journal-title":"Int J Recent Sci Res"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.59698"},{"issue":"3","key":"e_1_2_12_25_1","first-page":"27","article-title":"Study of the relationship between calcium ion and thyroid hormones, liver enzymes in some patients of hypocalcaemia and hypercalcaemia","volume":"1","author":"Abdullah JA","year":"2015","journal-title":"J Contemp Med Sci"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102008000100003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(90)90160-C"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02390.x"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:21:16Z","timestamp":1707916876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/hsr2.1669"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1669","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1669"}}