{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:38Z","timestamp":1753869218858,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The use of lidocaine aerosol for pediatric tonsil and adenoidectomy has been reported less frequently. We hope to improve the perioperative comfort of pediatric patients undergoing these procedures by applying lidocaine aerosol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 122 pediatric patients receiving tonsil and adenoidectomy were randomly divided into a lidocaine aerosol group (Group L) and a saline group (Group C), with 61 patients in each group; 2.4% alkaline lidocaine aerosol and saline were sprayed in the pharynx before induction. Our primary outcome were the incidence and rate ratio (RR) of postoperative pharyngeal complications (oropharyngeal dryness, dysphagia, hoarseness, and sore throat) and the pharyngeal comfort score, the latter of which was assessed by the occurrence of the above complications (yes\u2009=\u20090 point, none\u2009=\u20091 point). The secondary outcomes included preoperative and intraoperative blood pressure and heart rate, the incidence of choking during the induction period, the intraoperative opioid dosage, and the pain level and depth of sedation at 2, 6, and 24\u2009h postoperatively. Statistical software used in this study included PASS15.0, SPSS 26.0, and GraphPad Prism 9.3.1, and statistical methods used included the <jats:italic>t<\/jats:italic>\u2010test, the <jats:italic>\u03c7<\/jats:italic>\u00b2 test, the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, and the repeated measures analysis of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence and RR of postoperative pharyngeal complications such as oropharyngeal dryness (RR: 0.667, 95% confidence interval [CI]: 0.458\u20130.970, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), dysphagia (RR: 0.333, 95% CI: 0.114\u20130.976, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), hoarseness (RR: 0.647, 95% CI: 0.433\u20130.967, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), and sore throat (RR: 0.727, 95% CI: 0.547\u20130.967, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) were significantly lower in Group L than in Group C at 2\u2009h postoperatively, and the incidence and RR of postoperative sore throat was significantly lower in Group L than in Group C at 6\u2009h postoperatively (RR: 0.717, 95% CI: 0.547\u20130.942, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). The postoperative pharyngeal comfort scores were significantly higher in Group L than in Group C at all postoperative time points (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The Ramsay sedation score was significantly higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and FLACC (face, legs, activity, crying, and consolability) score was significantly lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) in Group L than in Group C at 2\u2009h postoperatively. In Group C, the blood pressure and heart rate significantly faster at all time points immediately after intubation and afterward, except at the end of surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pediatric tonsil and adenoidectomy, the application of lidocaine aerosol before induction can reduce the incidence of postoperative pharyngeal complications, improve the child's postoperative pharyngeal comfort, and better realize perioperative \u201ccomfort medical treatment.\u201d<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1688","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:58:47Z","timestamp":1699963127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lidocaine aerosol preoperative application for improving the comfort of pediatric patients undergoing tonsillectomy and adenoidectomy: A prospective randomized controlled trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Lixia","family":"Cheng","sequence":"first","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifen","family":"Ma","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingcai","family":"Peng","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Sun","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-0340","authenticated-orcid":false,"given":"Xiaoqiong","family":"Xia","sequence":"additional","affiliation":[{"name":"Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhai","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University Hefei 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