{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:06:50Z","timestamp":1784030810131,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10\u2009\u00b1\u20099.9 years) with confirmed methanol poisoning who were admitted to two hospitals in Iran during the COVID\u201019 pandemic. We analyzed their demographic, clinical, laboratory, and brain imaging data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main brain computed tomography\u00a0(CT) scan findings were hypodensity in the putamen (11.1%), cerebellar nuclei (8.2%), diffuse cerebral edema (7.5%), and intracranial hemorrhage (ICH; 1.6%). These findings were associated with blood pH, Glasgow Coma Scale (GCS), renal failure, bicarbonate, oxygen, carbon dioxide, potassium, and glucose levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Poor prognosis was related to blindness, opium addiction, chronic alcohol use, hyperglycemia, and abnormal CT scans (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all). The most predictive brain imaging findings for poor prognosis were hypodensity in the cerebellar nuclei, diffuse cerebral edema, and ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Brain imaging can provide valuable information for the diagnosis and management of methanol poisoning patients. We suggest that patients with severe acidosis, low GCS, low pH, low oxygen saturation, and high glucose levels should undergo brain CT scan as a priority.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1752","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:04:22Z","timestamp":1702443862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Methanol poisoning during the COVID\u201019 pandemic in Iran: A retrospective cross\u2010sectional study of clinical, laboratory, and brain imaging characteristics and outcomes"],"prefix":"10.1002","volume":"6","author":[{"given":"Saeid","family":"Esmaeilian","sequence":"first","affiliation":[{"name":"Health Policy Research Center, Institute of Health Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Teimouri","sequence":"additional","affiliation":[{"name":"Medical Imaging Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedighe","family":"Hooshmandi","sequence":"additional","affiliation":[{"name":"Medical Imaging Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Nikoo","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Centre Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-1137","authenticated-orcid":false,"given":"Seyed Taghi","family":"Heydari","sequence":"additional","affiliation":[{"name":"Health Policy Research Center, Institute of Health Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mohajeri","sequence":"additional","affiliation":[{"name":"Health Policy Research Center, Institute of Health Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bazmi","sequence":"additional","affiliation":[{"name":"Student Research Committee Fasa University of Medical Sciences  Fasa Iran"},{"name":"Noncommunicable Diseases Research Center Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Valiasr Hospital Fasa University of Medical Sciences  Fasa Iran"},{"name":"USERN office Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meisam","family":"Hoseinyazdi","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03202-0"},{"issue":"3","key":"e_1_2_10_3_1","article-title":"The diagnosis and management of toxic alcohol poisoning in the emergency department: a review article","volume":"3","author":"Gallagher N","year":"2019","journal-title":"Adv J Emerg Med"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2017.09.004"},{"issue":"2","key":"e_1_2_10_5_1","article-title":"Role of neuroimaging in methanol toxicity\u2014a case report","volume":"69","author":"Khan BM","year":"2019","journal-title":"Pak Armed Forces Med J"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2020-209886"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.03.029"},{"issue":"6","key":"e_1_2_10_8_1","first-page":"344","article-title":"A brief review on toxic alcohols: management strategies","volume":"10","author":"Hassanian\u2010Moghaddam H","year":"2016","journal-title":"Iran J Kidney Dis"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdu038"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agz005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2011.619193"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.2.371"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2020.1845192"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"452","article-title":"CT and MR imaging findings in methanol intoxication","volume":"27","author":"Blanco M","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5334\/jbsr.2836"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ncn3.12045"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.11.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190016"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-017-1651-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.11.026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152676"},{"issue":"10","key":"e_1_2_10_22_1","first-page":"865","article-title":"Role of clinical and paraclinical manifestations of methanol poisoning in outcome prediction","volume":"18","author":"Shadnia S","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agz028"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.4.402"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.4.0608"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.08.014"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2020.1845192"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","unstructured":"NikooMH EstedalA PakfetratM AbtahiF HeydariST. 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