{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:36:36Z","timestamp":1789605396768,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>With advancements in imaging and microelectrode recording techniques, general anesthesia (GA) has emerged as an alternative option for Parkinson's disease (PD) patients undergoing subthalamic nucleus deep brain stimulation (STN\u2010DBS). In this study, we compared the advantages and disadvantages of using GA and local anesthesia for STN\u2010DBS in enhanced recovery after surgery (ERAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surgical outcomes of STN\u2010DBS were evaluated using the unified PD rating scales (UPDRS). CT and magnetic resonance imaging scans are used to evaluate intracranial conditions. State\u2010trait anxiety inventory and hospital anxiety and depression scale are used to evaluate patients' perioperative psychology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anesthesia method does not significantly impact the accuracy of microelectrode placement or the improvement of postoperative symptoms. However, the local anesthesia group had a higher incidence of intracranial air, as well as higher rates of postoperative complications such as headache, dizziness, vomiting, and delirium. GA effectively alleviated preoperative anxiety and resulted in lower levels of perioperative anxiety and psychological stress compared to local anesthesia. Additionally, the GA group had shorter surgery duration, earlier ambulation, and a shorter average hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DBS under GA is safe and effective. Due to shorter surgical duration, reduced occurrence of perioperative complications, effective reduction of preoperative anxiety, and faster postoperative recovery, DBS under GA is better aligned with the concept of ERAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1766","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T04:58:15Z","timestamp":1702270695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The advantages of general anesthesia subthalamic deep brain stimulation for Parkinson's disease in the enhanced recovery after surgery: A randomized clinical trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Cunbao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Academy of Medical Sciences) Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0874-3963","authenticated-orcid":false,"given":"Taihong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Academy of Medical Sciences) Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy633"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2979"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000673"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12111469"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.8.JNS201125"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199902000-00031"},{"key":"e_1_2_10_7_2","unstructured":"Discussion13\u201014."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505079"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2017.224"},{"key":"e_1_2_10_10_1","article-title":"Five\u2010year clinical outcomes of local versus general anesthesia deep brain stimulation for Parkinson's disease","volume":"2019","author":"Tsai ST","year":"2019","journal-title":"Parkinson's Disease"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4952"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2023.101442"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-068910"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18550"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.10.176"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2021.04.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000764"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.12.84"},{"key":"e_1_2_10_19_1","volume-title":"Anesthetic Management for Enhanced Recovery After Major Surgery (ERAS)","author":"Tippireddy S","year":"2023"},{"issue":"19","key":"e_1_2_10_20_1","first-page":"339","article-title":"Perioperative psychological interventions in heart surgery\u2010opportunities and clinical benefit","volume":"118","author":"Tigges\u2010Limmer K","year":"2021","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20561"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-019-01220-2"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30289-5"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:56:03Z","timestamp":1704934563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/hsr2.1766"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1766","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1766"}}