{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:42:59Z","timestamp":1792082579918,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mass malaria vaccination, rather than vaccinating only children below age 5, has been proven to have the potential to reduce morbidity and mortality among those vaccinated, both young and old. Addressing vaccine scepticism and misinformation is crucial in African nations to build public trust in malaria prevention. Therefore, including a wider range of demographics in vaccine trials is necessary for equitable representation and achieving herd immunity against malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This present article aims to identify some of the obstacles that impede malaria vaccination usage and acceptability in African Nations in combating malaria in the region as it continues to pose a significant global public health problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A literature search was done on the Malaria vaccine between 2000 and 2023. Past and present articles\/studies on this topic were consulted on PubMed, Google Scholar, Scopus and Web of Science using the following keywords; \u201cMalaria,\u201d \u201cVaccines,\u201d \u201cAfrican Nations,\u201d \u201cObstacles, Strategies,\u201d and \u201cPublic Health.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recently approved RTS, S\/AS01, and R21\/Matrix\u2010M\u2122 Malaria vaccines have the potential to prevent numerous deaths and cases of Malaria in Africa. These vaccines Malaria vaccines are cost\u2010effective in African areas with moderate to high plasmodium falciparum and can be delivered through routine immunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To combat malaria effectively in African Nations, African leaders need to set up a comprehensive approach that involves; prevention, healthcare access, implementation research strategies towards adoption and acceptance of malaria vaccines in Africa as well as community engagement with the religious leaders, the market women, community heads, schools, as well as students\u2019 union towards the willingness and acceptability of the malaria vaccines among the African populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1797","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T04:23:50Z","timestamp":1704428630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Unlocking the potential of novel RTS, S\/AS01, and R21\/Matrix\u2010M\u2122 malaria vaccines in African nations"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-9891","authenticated-orcid":false,"given":"Malik Olatunde","family":"Oduoye","sequence":"first","affiliation":[{"name":"Department of Medical Education\/Research Medical Research Circle (MedReC) Bukavu Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Hospital Lahore King Edward Medical University Lahore Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4534","authenticated-orcid":false,"given":"Mohammed Dheyaa Marsool","family":"Marsool","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Al\u2010Kindy College of Medicine University of Baghdad Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9415-7673","authenticated-orcid":false,"given":"Mayowa Odunayo","family":"Kareem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Babcock University Teaching Hospital Ilishan\u2010Remo Ogun State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5926-1133","authenticated-orcid":false,"given":"Adenike Ebunoluwa","family":"Adedayo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9395-8190","authenticated-orcid":false,"given":"Abdulkarim Surajo","family":"Abdulkarim","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, College of Health Sciences Bayero University Kano Kano State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-9620","authenticated-orcid":false,"given":"Abdullahi Adeyemi","family":"Adegoke","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Ibadan Ibadan Oyo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-9279","authenticated-orcid":false,"given":"Ikshwaki","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Medicine David Tvildiani Medical University Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-7523","authenticated-orcid":false,"given":"Hamza","family":"Irfan","sequence":"additional","affiliation":[{"name":"Department of Medicine Shaikh Khalifa Bin Zayed Al Nahyan Medical and Dental College Lahore Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8631-3347","authenticated-orcid":false,"given":"Hassan Abdullahi","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, College of Health Sciences Bayero University Kano Kano State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain Haider","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3216-0617","authenticated-orcid":false,"given":"Karim Arif","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Research and Ethics Kamuzu University of Health Sciences Blantyre Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Malaria Report 2022.2022. Available from [Internet].\u00a0Accessed October 22 2023.https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-023-04714-z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0036"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0781-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31097-9"},{"key":"e_1_2_12_7_1","unstructured":"Global Data Healthcare. Overcoming vaccine scepticism in Africa will reduce malaria burden. Clinical Trials Arena. 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