{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:58:44Z","timestamp":1769993924349,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute pancreatitis is a significant and potentially life\u2010threatening gastrointestinal disorder that requires prompt and accurate diagnosis for effective treatment. Current diagnostic methods often involve expensive and inaccessible imaging studies, such as CT scans, limiting their utility in emergency settings and underserved areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This correspondence discusses an innovative and cost\u2010effective approach to assessing the severity of acute pancreatitis, focusing on the C\u2010Reactive Protein\u2010Albumin Ratio (CAR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We searched relevant articles and studies from 2015 till date on PubMed, Web of Science, and Google Scholar using these keywords: \u201cC\u2010Reactive Protein\u201d, \u201cAlbumin Ratio\u201d, \u201cAcute pancreatitis\u201d, \u201cCost\u2010effective\u201d, \u201cNon\u2010invasive\u201d, and \u201cSeverity\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The CAR diagnostic method involves a simple blood test that measures the levels of C\u2010Reactive Protein (CRP) and albumin, both commonly used markers for assessing inflammation. Elevated CRP and decreased albumin levels are indicative of inflammation, and the CAR has shown a strong positive correlation with the severity of acute pancreatitis. This method offers a non\u2010invasive, time\u2010efficient, and cost\u2010friendly alternative to traditional diagnostic techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The potential of CAR as an assessment tool for the severity of acute pancreatitis is highlighted, especially in resource\u2010limited settings. This innovation holds promise for improving the timely and accurate diagnosis of acute pancreatitis, ultimately enhancing patient outcomes and reducing mortality rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1801","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:59:55Z","timestamp":1704776395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CRP Albumin Ratio: A novel noninvasive and cost\u2010effective method for assessing the severity of acute pancreatitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Sania","family":"Ghaffar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ayub Medical College Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-3109","authenticated-orcid":false,"given":"Syeda","family":"Shahnoor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-8867","authenticated-orcid":false,"given":"Abdul Moiz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ayub Medical College Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimen","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ayub Medical College Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Fida","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ayub Medical College Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-9891","authenticated-orcid":false,"given":"Malik Olatunde","family":"Oduoye","sequence":"additional","affiliation":[{"name":"Department of Research at Medical Research Circle in Bukavu Democratic Republic of Congo Bukavu Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-3824","authenticated-orcid":false,"given":"Wechuli Polyne","family":"Nafula","sequence":"additional","affiliation":[{"name":"Department of clinical medicine Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01859-5"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01766-4"},{"issue":"3","key":"e_1_2_1_7_4_1","first-page":"337","article-title":"Prognostic scores in acute pancreatitis: a review","volume":"79","author":"Balc\u0131 Z","year":"2016","journal-title":"Acta Gastro\u2010Enterol Belg"},{"issue":"01","key":"e_1_2_1_7_5_1","first-page":"2695","article-title":"Accuracy of neutrophil to lymphocyte ratio (NLR) as a predictor of severe acute pancreatitis keeping balthazar CT scan severity index score as gold standard","volume":"26","author":"Rind W","year":"2022","journal-title":"Anna Roma Soc Cell Biol"},{"issue":"6","key":"e_1_2_1_7_6_1","first-page":"06","article-title":"CT evaluation of acute pancreatitis and its prognostic correlation with CT severity index","volume":"10","author":"Raghuwanshi S","year":"2016","journal-title":"J Clin Diagnos Res"},{"key":"e_1_2_1_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.12.017"},{"issue":"1","key":"e_1_2_1_7_8_1","first-page":"81","article-title":"Comparison of the efficacy of Balthazar score and C\u2010reactive protein\u2010albumin ratio for determination of acute pancreatitis severity","volume":"48","author":"Kiyak M","year":"2022","journal-title":"Curr Health Sci J"},{"key":"e_1_2_1_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035979"},{"key":"e_1_2_1_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1026604"},{"key":"e_1_2_1_7_11_1","unstructured":"How Much Does a CT Scan Cost Without Insurance? Here's Everything You Need to Know | Curative [Internet]. How Much Does a CT Scan Cost Without Insurance? Here's Everything You Need to Know | Curative.https:\/\/curative.com\/blog\/how-much-does-a-ct-scan-cost-without-insurance"},{"key":"e_1_2_1_7_12_1","unstructured":"Mdsave.com. 2023. Accesed November 15 2023.https:\/\/www.mdsave.com\/procedures\/albumin-test\/d782fbcd"},{"key":"e_1_2_1_7_13_1","unstructured":"CRP Test Cost [Internet]. Find Lab Tests Online. 2023.https:\/\/www.findlabtest.com\/lab-test\/immunological-testing\/crp-test-cost-quest-4420"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.1801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:32:41Z","timestamp":1707287561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.1801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/hsr2.1801"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.1801","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1801"}}